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0ACOD_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameSCD
DescriptionAcyl-coa desaturase (ec 1.14.19.1) (stearoyl-coa desaturase) (fatty acid desaturase) (delta(9)-desaturase).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0004768 stearoyl-CoA 9-desaturase activity (TAS)
Domain Architecture (Details)
InterPro domains unassigned to SynO:
Fatty acid desaturases are enzymes that catalyze the insertionof a double bond at the delta position of fatty acids. There seem to be two distinct families of fatty acid desaturases which do not seem to be evolutionary related. This entry is family 2 of the desaturases andincludes.lant stearoyl-acyl-carrier-protein desaturase () that catalysesthe introduction of a double bond at the delta position of steraoyl-ACP to produce oleoyl-ACP and is responsible for the conversion of saturated fatty acids to unsaturated fatty acids in the synthesis of vegetable oils.nd Cyanobacteria desA an enzyme that can introduce a second cis double bond at the delta position of fatty acid bound to membranes glycerolipids. DesA is involved in chilling tolerance; the phase transition temperature of lipids of cellular membranes being dependent on the degree of unsaturation of fatty acids of the membrane lipids.
  IPR005804:Fatty acid desaturase
Fatty acid desaturases are enzymes that catalyze the insertion of a double bond at the delta position of fatty acids.There seems to be two distinct families of fatty acid desaturases which do not seem to be evolutionary related: the first contains stearoyl-CoA desaturase (SCD) (); the second includes plant stearoyl-acyl-carrier protein and cyanobacteria desA protein.SCD is a key regulatory enzyme of unsaturated fatty acid biosynthesis. In association with cytochrome b5 and NADP-dependent cytochrome b5 reductase.t constitutes part of a microsomal membrane-bound 3-component system in animals and fungi . SCD contains 4 putative transmembrane (TM) regions that anchor it in the microsomal membrane. SCD uses oxygen and electrons from reduced cytochrome b5 .o catalyse the insertion of a cis double bond between carbons 9 and 10 of a spectrum of fatty acids . The preferred substrates of SCD are palmitoyl-CoA and stearoyl-CoA.hich are converted to palmitoleic (16:1) and oleic (18:1) acids respectively . These unsaturated molecules are the major storage form of fatty acids (as triacylglycerols) in adipocytes .
  IPR001522:Fatty acid desaturase, type 1
Fatty acid desaturases are enzymes that catalyze the insertion of a double bond at the delta position of fatty acids.There seems to be two distinct families of fatty acid desaturases which do not seem to be evolutionary related: the first contains stearoyl-CoA desaturase (SCD) (); the second includes plant stearoyl-acyl-carrier protein and cyanobacteria desA protein.SCD is a key regulatory enzyme of unsaturated fatty acid biosynthesis. In association with cytochrome b5 and NADP-dependent cytochrome b5 reductase.t constitutes part of a microsomal membrane-bound 3-component system in animals and fungi . SCD contains 4 putative transmembrane (TM) regions that anchor it in the microsomal membrane. SCD uses oxygen and electrons from reduced cytochrome b5 .o catalyse the insertion of a cis double bond between carbons 9 and 10 of a spectrum of fatty acids . The preferred substrates of SCD are palmitoyl-CoA and stearoyl-CoA.hich are converted to palmitoleic (16:1) and oleic (18:1) acids respectively . These unsaturated molecules are the major storage form of fatty acids (as triacylglycerols) in adipocytes .
  IPR010257:Fatty acid desaturase subdomain
This family contains a group acyl-CoA desaturases (acyl-CoA desaturases 1).hich are sometimes referred to as animal-type fatty acid desaturases.ven though the group contains bacterial and a few plant enzymes. This term is used to distinguish them from acyl-ACP desaturases (plant-type fatty acid desaturases. which are structurally unrelated to acyl-CoA desaturases. Therefore.lant enzymes are closely related to animal and fungal acyl-CoA desaturases and structurally unrelated to the major group of plant acyl-ACP desaturases (). This family includes predominantly delta-9 fatty acid desaturases ().ut also acyl-CoA delta-11-desaturase and other acyl-CoA desaturases. Animal members function in unsaturated fatty acid biosynthesis.atalysing the insertion of a double bond at the delta position of fatty acids . The experimentally characterised members convert stearoyl-CoA to oleoyl-CoA . Both palmitoyl-CoA desaturase and stearoyl-CoA desaturase activities are present in most of these enzymes.ut some show preference for one or the other.nd some have mostly palmitoyl-CoA desaturase activity . Family members that come from plants may have different (and for many proteins not yet characterised) substrate specificities .
  IPR012196:Acyl-CoA desaturase
IPR005804:FA_desaturase 
Evalue:-80.3979415893555 
Location:96-321IPR001522:FACDDSATRASE 
Evalue:0 
Location:73-93
SequencesProtein: ACOD_HUMAN (359 aa)
mRNA: NM_005063
Local Annotation
Synapse Ontology
Calcium release from RyR (Ryanodine Receptor) in the SR (Sarcoplasmic Reticulum) is activated by the calcium induced-calcium-release
sdb:0325 RyR-CICR  (Evidence:keywords)
KO assignmentK00507
  Level 3 annotation:
    stearoyl-CoA desaturase
  Level 2 annotation:
    Other lipid metabolism
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 173 residues, 102096761-102097278Exon2: 96 residues, 102097810-102098093Exon3: 45 residues, 102102112-102102243Exon4: 70 residues, 102104173-102104379Exon5: 79 residues, 102106278-102106511Exon6: 1367 residues, 102110480-102114577Exon7: 2 residues, -Jump to ACOD_HUMAN  
Tune and view alternative isoforms
Loci Cluster (Details)Loci: 3916 101461595-101481890 ~-20K 5514(COX15)(-)Loci: 2628 101532562-101601571 ~-69K 5517(ABCC2)(+)Loci: 3917 101625324-101759666 ~-134K 5519(DNMBP)(-)Loci: 2629 102096761-102114577 ~-18K 5532(SCD)(+)Loci: 3918 102273487-102279626 ~-6K 5541(NDUFB8)(-)Loci: 3919 102727568-102737262 ~-10K 5557(MRPL43)(-)Loci: 3915 101146617-101180336 ~-34K 5507(GOT1)(-)Link out to UCSC