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0ACM4_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameCHRM4
DescriptionMuscarinic acetylcholine receptor m4.
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005887 integral to plasma membrane (TAS)
0005886 plasma membrane (TAS)
0004981 muscarinic acetylcholine receptor activity (TAS)
0007213 acetylcholine receptor signaling, muscarini... (TAS)
0008283 cell proliferation (TAS)
0007166 cell surface receptor linked signal transdu... (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains assigned to SynO:
G-protein-coupled receptors.PCRs.onstitute a vast protein family that encompasses a wide range of functions (including various autocrine.aracrine and endocrine processes). They show considerable diversity at the sequence level.n the basis of which they can be separated into distinct groups. We use the term clan to describe the GPCRs.s they embrace a group of families for which there are indications of evolutionary relationship.ut between which there is no statistically significant similarity in sequence . The currently known clan members include the rhodopsin-like GPCRs.he secretin-like GPCRs.he cAMP receptors.he fungal mating pheromone receptors.nd the metabotropic glutamate receptor family. There is a specialized database for GPCRs: http://www.gpcr.org/7tm/. The rhodopsin-like GPCRs themselves represent a widespread protein family that includes hormone.eurotransmitter and light receptors.ll of which transduce extracellular signals through interaction with guanine nucleotide-binding (G) proteins. Although their activating ligands vary widely in structure and character.he amino acid sequences of the receptors are very similar and are believed to adopt a common structural framework comprising 7transmembrane (TM) helices .The muscarinic acetylcholine receptors.resent in the central nervoussystem.pinal cord motoneurons and autonomic preganglia.odulate avariety of physiological functions: these include airway.ye and intestinalsmooth muscle contractions; heart rate; and glandular secretions. Thereceptors mediate adenylate cyclase attenuation.alcium and potassiumchannel activation.nd phosphatidyl inositol turnover . This diversitymay result from the occurrence of multiple receptor subtypes.hich havebeen classified based on observed differences in ligand binding toreceptors in membranes from several tissues.
  IPR000995:Muscarinic acetylcholine receptor
InterPro domains unassigned to SynO:
G-protein-coupled receptors.PCRs.onstitute a vast protein family that encompasses a wide range of functions (including various autocrine.aracrine and endocrine processes). They show considerable diversity at the sequence level.n the basis of which they can be separated into distinct groups. We use the term clan to describe the GPCRs.s they embrace a group of families for which there are indications of evolutionary relationship.ut between which there is no statistically significant similarity in sequence . The currently known clan members include the rhodopsin-like GPCRs.he secretin-like GPCRs.he cAMP receptors.he fungal mating pheromone receptors.nd the metabotropic glutamate receptor family. There is a specialized database for GPCRs: http://www.gpcr.org/7tm/. The rhodopsin-like GPCRs themselves represent a widespread protein family that includes hormone.eurotransmitter and light receptors.ll of which transduce extracellular signals through interaction with guanine nucleotide-binding (G) proteins. Although their activating ligands vary widely in structure and character.he amino acid sequences of the receptors are very similar and are believed to adopt a common structural framework comprising 7transmembrane (TM) helices .
  IPR000276:Rhodopsin-like GPCR superfamily
G-protein-coupled receptors.PCRs.onstitute a vast protein family that encompasses a wide range of functions (including various autocrine.aracrine and endocrine processes). They show considerable diversity at the sequence level.n the basis of which they can be separated into distinct groups. We use the term clan to describe the GPCRs.s they embrace a group of families for which there are indications of evolutionary relationship.ut between which there is no statistically significant similarity in sequence . The currently known clan members include the rhodopsin-like GPCRs.he secretin-like GPCRs.he cAMP receptors.he fungal mating pheromone receptors.nd the metabotropic glutamate receptor family. There is a specialized database for GPCRs: http://www.gpcr.org/7tm/. The rhodopsin-like GPCRs themselves represent a widespread protein family that includes hormone.eurotransmitter and light receptors.ll of which transduce extracellular signals through interaction with guanine nucleotide-binding (G) proteins. Although their activating ligands vary widely in structure and character.he amino acid sequences of the receptors are very similar and are believed to adopt a common structural framework comprising 7transmembrane (TM) helices .The muscarinic acetylcholine receptors.resent in the central nervoussystem.pinal cord motoneurons and autonomic preganglia.odulate avariety of physiological functions: these include airway.ye and intestinalsmooth muscle contractions; heart rate; and glandular secretions. Thereceptors mediate adenylate cyclase attenuation.alcium and potassiumchannel activation.nd phosphatidyl inositol turnover . This diversitymay result from the occurrence of multiple receptor subtypes.hich havebeen classified based on observed differences in ligand binding toreceptors in membranes from several tissues.The M4 receptor is found in high levels in neuronal cells of the CNS; its distribution largely overlaps with that of M1 and M3 subtypes. It is also found in cell lines. No selective agonist has been described .
  IPR001432:Muscarinic acetylcholine receptor M4
IPR000276:7tm_1 
Evalue:-84.3187561035156 
Location:49-453IPR000995:MUSCARINICR 
Evalue:0 
Location:456-470IPR000995:MUSCARINICR 
Evalue:0 
Location:34-46
SequencesProtein: ACM4_HUMAN (479 aa)
mRNA: NM_000741
Local Annotation
Synapse Ontology
Postsynaptic compartment is represented by a patch of plasma membrane containing a packed array of neurotransmitter receptors and by an underlying dense matrix, the postsynaptic density (PSD).
sdb:0005 Postsynaptic compartment  (Evidence:keywords,domains)
?
sdb:0219 GPCR mediated signaling  (Evidence:keywords,domains)
?
sdb:0334 inhibitory postsynapstic component  (Evidence:keywords,domains)
KO assignmentK04132
  Level 3 annotation:
    cholinergic receptor, muscarinic 4
  Level 2 annotation:
    G-protein coupled receptors
    Neuroactive ligand-receptor interaction
    Regulation of actin cytoskeleton
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 490 residues, 46363215-46364683Exon2: 2 residues, -Jump to ACM4_HUMAN  
Tune and view alternative isoforms
Loci Cluster (Details)Loci: 2662 45863777-45884591 ~-21K 6614(MAPK8IP1)(+)Loci: 2663 46323559-46358680 ~-35K 6625(+)Loci: 3947 46363215-46364683 ~-1K 6632(CHRM4)(-)Loci: 2661 45825604-45861372 ~-36K 6612(+)Link out to UCSC