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0ACM1_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameCHRM1
DescriptionMuscarinic acetylcholine receptor m1.
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005887 integral to plasma membrane (TAS)
0005624 membrane fraction (TAS)
0005886 plasma membrane (TAS)
0004981 muscarinic acetylcholine receptor activity (TAS)
0004435 phosphoinositide phospholipase C activity (TAS)
0007213 acetylcholine receptor signaling, muscarini... (TAS)
0008283 cell proliferation (TAS)
0007207 muscarinic acetylcholine receptor, phosphol... (TAS)
0007399 neurogenesis (TAS)
0008284 positive regulation of cell proliferation (TAS)
0007205 protein kinase C activation (TAS)
0006464 protein modification (TAS)
0007165 signal transduction (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains assigned to SynO:
G-protein-coupled receptors.PCRs.onstitute a vast protein family that encompasses a wide range of functions (including various autocrine.aracrine and endocrine processes). They show considerable diversity at the sequence level.n the basis of which they can be separated into distinct groups. We use the term clan to describe the GPCRs.s they embrace a group of families for which there are indications of evolutionary relationship.ut between which there is no statistically significant similarity in sequence . The currently known clan members include the rhodopsin-like GPCRs.he secretin-like GPCRs.he cAMP receptors.he fungal mating pheromone receptors.nd the metabotropic glutamate receptor family. There is a specialized database for GPCRs: http://www.gpcr.org/7tm/. The rhodopsin-like GPCRs themselves represent a widespread protein family that includes hormone.eurotransmitter and light receptors.ll of which transduce extracellular signals through interaction with guanine nucleotide-binding (G) proteins. Although their activating ligands vary widely in structure and character.he amino acid sequences of the receptors are very similar and are believed to adopt a common structural framework comprising 7transmembrane (TM) helices .The muscarinic acetylcholine receptors.resent in the central nervoussystem.pinal cord motoneurons and autonomic preganglia.odulate avariety of physiological functions: these include airway.ye and intestinalsmooth muscle contractions; heart rate; and glandular secretions. Thereceptors mediate adenylate cyclase attenuation.alcium and potassiumchannel activation.nd phosphatidyl inositol turnover . This diversitymay result from the occurrence of multiple receptor subtypes.hich havebeen classified based on observed differences in ligand binding toreceptors in membranes from several tissues.
  IPR000995:Muscarinic acetylcholine receptor
InterPro domains unassigned to SynO:
G-protein-coupled receptors.PCRs.onstitute a vast protein family that encompasses a wide range of functions (including various autocrine.aracrine and endocrine processes). They show considerable diversity at the sequence level.n the basis of which they can be separated into distinct groups. We use the term clan to describe the GPCRs.s they embrace a group of families for which there are indications of evolutionary relationship.ut between which there is no statistically significant similarity in sequence . The currently known clan members include the rhodopsin-like GPCRs.he secretin-like GPCRs.he cAMP receptors.he fungal mating pheromone receptors.nd the metabotropic glutamate receptor family. There is a specialized database for GPCRs: http://www.gpcr.org/7tm/. The rhodopsin-like GPCRs themselves represent a widespread protein family that includes hormone.eurotransmitter and light receptors.ll of which transduce extracellular signals through interaction with guanine nucleotide-binding (G) proteins. Although their activating ligands vary widely in structure and character.he amino acid sequences of the receptors are very similar and are believed to adopt a common structural framework comprising 7transmembrane (TM) helices .
  IPR000276:Rhodopsin-like GPCR superfamily
G-protein-coupled receptors.PCRs.onstitute a vast protein family that encompasses a wide range of functions (including various autocrine.aracrine and endocrine processes). They show considerable diversity at the sequence level.n the basis of which they can be separated into distinct groups. We use the term clan to describe the GPCRs.s they embrace a group of families for which there are indications of evolutionary relationship.ut between which there is no statistically significant similarity in sequence . The currently known clan members include the rhodopsin-like GPCRs.he secretin-like GPCRs.he cAMP receptors.he fungal mating pheromone receptors.nd the metabotropic glutamate receptor family. There is a specialized database for GPCRs: http://www.gpcr.org/7tm/. The rhodopsin-like GPCRs themselves represent a widespread protein family that includes hormone.eurotransmitter and light receptors.ll of which transduce extracellular signals through interaction with guanine nucleotide-binding (G) proteins. Although their activating ligands vary widely in structure and character.he amino acid sequences of the receptors are very similar and are believed to adopt a common structural framework comprising 7transmembrane (TM) helices .The muscarinic acetylcholine receptors.resent in the central nervoussystem.pinal cord motoneurons and autonomic preganglia.odulate avariety of physiological functions: these include airway.ye and intestinalsmooth muscle contractions; heart rate; and glandular secretions. Thereceptors mediate adenylate cyclase attenuation.alcium and potassiumchannel activation.nd phosphatidyl inositol turnover . This diversitymay result from the occurrence of multiple receptor subtypes.hich havebeen classified based on observed differences in ligand binding toreceptors in membranes from several tissues.The M1 receptor is found in high levels in neuronal cells of the CNS; itis particularly abundant in the cerebral cortex and hippocampus. Itsdistribution largely overlaps with that of M3 and M4 subtypes. In theperiphery.1 receptors are found in autonomic ganglia and certainsecretory glands.nd they are also found in cell lines. No trulyselective agonist has been described .
  IPR002228:Muscarinic acetylcholine receptor M1
G-protein-coupled receptors.PCRs.onstitute a vast protein family that encompasses a wide range of functions (including various autocrine.aracrine and endocrine processes). They show considerable diversity at the sequence level.n the basis of which they can be separated into distinct groups. We use the term clan to describe the GPCRs.s they embrace a group of families for which there are indications of evolutionary relationship.ut between which there is no statistically significant similarity in sequence . The currently known clan members include the rhodopsin-like GPCRs.he secretin-like GPCRs.he cAMP receptors.he fungal mating pheromone receptors.nd the metabotropic glutamate receptor family. There is a specialized database for GPCRs: http://www.gpcr.org/7tm/. The rhodopsin-like GPCRs themselves represent a widespread protein family that includes hormone.eurotransmitter and light receptors.ll of which transduce extracellular signals through interaction with guanine nucleotide-binding (G) proteins. Although their activating ligands vary widely in structure and character.he amino acid sequences of the receptors are very similar and are believed to adopt a common structural framework comprising 7transmembrane (TM) helices .5-Hydroxytryptamine (or serotonin) is ubiquitous in plants and animals. It is an important neurotransmitter and local hormone in the CNS and intestine.nd is implicated in a vast array of physiological and pathophysiological pathways. In the periphery.HT contracts a number of smooth muscles.nd induces endothelium-dependent vasodilation through the formation of NO. It is a mediator of peristalsis.nd may be involved in platelet aggregation and homeostasis. In the CNS.HT is believed to be involved in a wide range of functions.ncluding the control of appetite.ood.nxiety.allucinations.leep.omiting and pain perception 5HT receptor ligands are of clinical use in the treatment of depression.igraine and post-operative vomiting.Numerous receptor subtypes have been classified according to their antagonist susceptibilities and their affinities for 5HT. Five 5HT1 subtypes and at least three 5HT2 subtypes have now been identified.n addition to subtypes 5HT3-7 . All share a high degree of sequence similarity.nd have overlapping pharmacological specificities.The 5HT5 receptor has a similar pharmacology to the 5HT1D receptor. Inthe CNS.ts mRNA is found in the cerebral cortex.ippocampus.abenula.lfactory bulb and granular layer of the cerebellum. There are noselective agonists.nd the receptor does not appear to be linked to theadenylyl cyclase or phosphoinositide pathways .
  IPR002232:5-Hydroxytryptamine 6 receptor
IPR000276:7tm_1 
Evalue:-100.431800842285 
Location:42-418IPR002232:5HT6RECEPTR 
Evalue:0 
Location:15-32IPR002228:MUSCRINICM1R 
Evalue:0 
Location:441-458IPR000995:MUSCARINICR 
Evalue:0 
Location:421-435
SequencesProtein: ACM1_HUMAN (460 aa)
mRNA: NM_000738
Local Annotation
Synapse Ontology
Postsynaptic compartment is represented by a patch of plasma membrane containing a packed array of neurotransmitter receptors and by an underlying dense matrix, the postsynaptic density (PSD).
sdb:0005 Postsynaptic compartment  (Evidence:keywords,domains)
activation of protein kinase C
sdb:0206 activation of protein kinase C  (Evidence:keywords,domains)
?
sdb:0219 GPCR mediated signaling  (Evidence:keywords,domains)
?
sdb:0334 inhibitory postsynapstic component  (Evidence:keywords,domains)
KO assignmentK04129
  Level 3 annotation:
    cholinergic receptor, muscarinic 1
  Level 2 annotation:
    Calcium signaling pathway
    G-protein coupled receptors
    Neuroactive ligand-receptor interaction
    Regulation of actin cytoskeleton
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 834 residues, 62432727-62435226Exon2: 109 residues, 62445265-62445588Exon3: 2 residues, -Jump to ACM1_HUMAN  
Tune and view alternative isoforms
Loci Cluster (Details)Loci: 2668 62137198-62139162 ~-2K 6915(ROM1)(+)Loci: 3955 62148876-62170680 ~-22K 6917(GANAB)(-)Loci: 2669 62252159-62262681 ~-11K 6930(+)Loci: 3956 62330945-62356116 ~-25K 6938(STX5A)(-)Loci: 2670 62380093-62412928 ~-33K 6943(SLC3A2)(+)Loci: 3957 62432727-62445588 ~-13K 6949(CHRM1)(-)Loci: 3954 62117250-62125879 ~-9K 6910(MTA2)(-)Link out to UCSC