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0ACINU_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameACIN1
DescriptionApoptotic chromatin condensation inducer in the nucleus (acinus).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005634 nucleus (IDA)
0016887 ATPase activity (NAS)
0019899 enzyme binding (NAS)
0003676 nucleic acid binding (NAS)
0030263 apoptotic chromosome condensation (IDA)
0030218 erythrocyte differentiation (IEP)
0045657 positive regulation of monocyte differentia... (IEP)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
The SAP (after SAF-A/B.cinus and PIAS) motif is a putativeDNA binding domain found in diverse nuclear proteins involved in chromosomal organization .
  IPR003034:DNA-binding SAP
Many eukaryotic proteins that are known or supposed to bind single-stranded RNA contain one or more copies of a putative RNA-binding domain of about 90 amino acids. This is known as the eukaryotic putative RNA-binding region RNP-1 signature or RNA recognition motif (RRM). RRMs are found in a variety of RNA binding proteins.ncluding heterogeneous nuclear ribonucleoproteins (hnRNPs).roteins implicated in regulation of alternative splicing.nd protein components of small nuclear ribonucleoproteins (snRNPs). The RRM in heterodimeric splicing factor U2 snRNP auxiliary factor (U2AF) appears to have two RRM-like domains with specialized features for protein recognition . The motif also appears in a few single stranded DNA binding proteins. The RRM structure consists of four strands and two helices arranged in an alpha/beta sandwich.ith a third helix present during RNA binding in some cases .
  IPR000504:RNA-binding region RNP-1 (RNA recognition motif)
This entry represents nucleotide-binding domains with an alpha-beta plait structure.hich consists of either a ferredoxin-like (beta-alpha-beta)2 fold.uch as that found in RNA-binding domains of various ribonucleoproteins or in viral DNA-binding domains . or a beta-(alpha)-beta-alpha-beta(2) fold.uch as that found in the ribosomal protein L23 .
  IPR012677:Nucleotide-binding, alpha-beta plait
IPR003034:SAP 
Evalue:-9.82390880584717 
Location:72-106IPR000504:RRM 
Evalue:-1.08092190762393 
Location:1013-1082
SequencesProtein: ACINU_HUMAN (1341 aa)
mRNA: NM_014977
Local Annotation
Synapse Ontology
A process that increases short-term neuronal synaptic plasticity, the ability of neuronal synapses to change in the short-term as circumstances require. Short-term neuronal synaptic plasticity generally involves increasing or decreasing synaptic sensitivity.
sdb:0043 positive regulation of short-term neuronal synaptic plasticity  (Evidence:keywords)
the plasma membrane of the postsynaptic neuron. It apposes with presynaptic actiove zone.
sdb:0108 postsynaptic plasma membrane  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 303 residues, 22597615-22598523Exon2: 35 residues, 22600132-22600233Exon3: 110 residues, 22600346-22600671Exon4: 38 residues, 22601216-22601324Exon5: 38 residues, 22601464-22601572Exon6: 50 residues, 22601977-22602123Exon7: 49 residues, 22602484-22602626Exon8: 53 residues, 22603153-22603306Exon9: 46 residues, 22603403-22603537Exon10: 16 residues, 22605014-22605057Exon11: 49 residues, 22608524-22608666Exon12: 40 residues, 22617199-22617315Exon13: 75 residues, 22617868-22618087Exon14: 423 residues, 22618595-22619858Exon15: 31 residues, 22620796-22620885Exon16: 42 residues, 22629030-22629150Exon17: 39 residues, 22629570-22629682Exon18: 24 residues, 22632527-22632593Exon19: 215 residues, 22634023-22634663Exon20: 2 residues, -Jump to ACINU_HUMAN  
Tune and view alternative isoforms
Loci Cluster (Details)Loci: 4116 22525950-22549192 ~-23K 10843(C14orf93)(-)Loci: 4117 22597615-22634663 ~-37K 10853(ACIN1)(-)Loci: 2824 22845875-22850798 ~-5K 10860(BCL2L2)(+)Loci: 2825 22859236-22865202 ~-6K 10861(PABPN1)(+)Loci: 4118 22895451-22904682 ~-9K 10864(EFS)(-)Loci: 4119 22921038-22947324 ~-26K 10871(MYH6)(-)Loci: 4120 22951789-22973312 ~-22K 10872(MYH7)(-)Loci: 4121 23059904-23065839 ~-6K 10876(ZFHX2)(-)Loci: 4122 23098616-23107119 ~-9K 10881(AP1G2)(-)Loci: 4115 22439745-22458214 ~-18K 10832(RBM23)(-)Link out to UCSC