SynDB Home Page
SynDB Home Page
Browse
Search
Download
Help
People
links

blue bulletSynDB protein details  


Parse error: syntax error, unexpected T_VARIABLE in /home/kongl/syndb/www/sdb_nats.php on line 52
0ACHG_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameCHRNG
DescriptionAcetylcholine receptor protein, gamma subunit precursor.
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005887 integral to plasma membrane (TAS)
0015464 acetylcholine receptor activity (TAS)
0015267 channel or pore class transporter activity (TAS)
0006936 muscle contraction (TAS)
0007165 signal transduction (TAS)
0006810 transport (TAS)

Warning: fopen(/home/kongl/syndb/www/temp/542946455.dot) [function.fopen]: failed to open stream: Permission denied in /home/kongl/syndb/www/sdb_pro.php on line 269

Warning: fwrite(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 270

Warning: fwrite(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 271

Warning: fwrite(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 272

Warning: fwrite(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 273

Warning: fwrite(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 274

Warning: fwrite(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 299

Warning: fclose(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 300
schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains assigned to SynO:
Neurotransmitter ligand-gated ion channels are transmembrane receptor-ion channel complexes that open transiently upon binding of specific ligands.llowing rapid transmission of signals at chemical synapses .Of the five families known.our have been shown to form a sequence-related superfamily. These are the gamma-aminobutyric acid type A (GABA-A).icotinic acetylcholine.lycine and the serotonin 5HT3 receptors. The ionotropic glutamate receptors () have a distinct primary structure.However.ll these receptors possess a pentameric structure (made up of varying subunits).urrounding a central pore. Each of these subunits contains a large extracellular N-terminal ligand-binding region; 3 hydrophobic transmembrane domains; a large intracellular region; and a fourth hydrophobic domain .This domain represents four transmembrane helices of a variety of neurotransmitter-gated ion-channels.
  IPR006029:Neurotransmitter-gated ion-channel transmembrane region
Neurotransmitter ligand-gated ion channels are transmembrane receptor-ion channel complexes that open transiently upon binding of specific ligands.llowing rapid transmission of signals at chemical synapses .Of the five families known.our have been shown to form a sequence-related superfamily. These are the gamma-aminobutyric acid type A (GABA-A).icotinic acetylcholine.lycine and the serotonin 5HT3 receptors. The ionotropic glutamate receptors () have a distinct primary structure.However.ll these receptors possess a pentameric structure (made up of varying subunits).urrounding a central pore. Each of these subunits contains a large extracellular N-terminal ligand-binding region; 3 hydrophobic transmembrane domains; a large intracellular region; and a fourth hydrophobic domain .This InterPro entry represents the GABA-A.icotinic.lycine.nd 5HT3 receptors.
  IPR006201:Neurotransmitter-gated ion-channel
InterPro domains unassigned to SynO:
Neurotransmitter ligand-gated ion channels are transmembrane receptor-ion channel complexes that open transiently upon binding of specific ligands.llowing rapid transmission of signals at chemical synapses .Of the five families known.our have been shown to form a sequence-related superfamily. These are the gamma-aminobutyric acid type A (GABA-A).icotinic acetylcholine.lycine and the serotonin 5HT3 receptors. The ionotropic glutamate receptors () have a distinct primary structure.However.ll these receptors possess a pentameric structure (made up of varying subunits).urrounding a central pore. Each of these subunits contains a large extracellular N-terminal ligand-binding region; 3 hydrophobic transmembrane domains; a large intracellular region; and a fourth hydrophobic domain .Nicotinic acetylcholine receptors are ligand-gated ion channels that mediate signaltransduction at the post-synaptic membrane of cholinergic synapses.uch asthe neuromuscular junction . They belong to a family of neurotransmitter-gated receptors.ncluding glycine.amma-aminobutyric-acid (GABA).erotonin 5HT3 receptors. These are oligomeric transmembrane(TM) complexes (pentamers of 2 alpha and 1 beta. gamma and 1 deltasubunit) that contain a central channel.hich transiently opens upon binding of a specific neurotransmitters. Their sequences are related and share the same topology: each hasan extracellular.lycosylated N-terminal ligand-binding domain; 3 hydrophobic TM regions.hich form the channel; a hydrophilic cytoplasmicdomain; followed by a fourth putative TM region . The nicotinic receptor ligand binding domain is a specialized pocket of aromatic and hydrophobic residues formed at interfaces between protein subunits that changes conformation to convert agonist binding into gating of an intrinsic ion channel . The expression of acetylcholine receptors is activated during muscledifferentiation and upon denervation of adult muscle . Receptor functionis regulated by phosphorylation and dephosphorylation by kinases andphosphatases present in the post-synaptic membranes . Most of thephosphorylation sites are located in the major intracellular loop betweenthe third and fourth TM regions and are closely spaced.
  IPR002394:Nicotinic acetylcholine receptor
Neurotransmitter ligand-gated ion channels are transmembrane receptor-ion channel complexes that open transiently upon binding of specific ligands.llowing rapid transmission of signals at chemical synapses .Of the five families known.our have been shown to form a sequence-related superfamily. These are the gamma-aminobutyric acid type A (GABA-A).icotinic acetylcholine.lycine and the serotonin 5HT3 receptors. The ionotropic glutamate receptors () have a distinct primary structure.However.ll these receptors possess a pentameric structure (made up of varying subunits).urrounding a central pore. Each of these subunits contains a large extracellular N-terminal ligand-binding region; 3 hydrophobic transmembrane domains; a large intracellular region; and a fourth hydrophobic domain .This entry presents the extracellular ligand binding domain of these ion channels. This domain forms a pentameric arrangement in the known structure.
  IPR006202:Neurotransmitter-gated ion-channel ligand-binding
IPR006202:Neur_chan_LBD 
Evalue:-106.05061340332 
Location:26-241IPR006029:Neur_chan_memb 
Evalue:-87.2006607055664 
Location:248-492
SequencesProtein: ACHG_HUMAN (517 aa)
mRNA: NM_005199
Local Annotation
Synapse Ontology
Postsynaptic compartment is represented by a patch of plasma membrane containing a packed array of neurotransmitter receptors and by an underlying dense matrix, the postsynaptic density (PSD).
sdb:0005 Postsynaptic compartment  (Evidence:keywords,domains)
this kind of receptor usually locates at the postsynaptic plasma membranous region.
sdb:0109 ionotropic receptor  (Evidence:keywords,domains)
priming for exocytosis prepares the calcium-dependent release and may involve partial fusion process. The vesicles are primed and become responsive to calcium.
sdb:0120 priming  (Evidence:keywords,domains)
?
sdb:0305 binding to postsynaptic receptor and internization  (Evidence:keywords,domains)
KO assignmentK04818
  Level 3 annotation:
    cholinergic receptor, nicotinic, gamma polypeptide
  Level 2 annotation:
    Ion channels
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 26 residues, 233112680-233112756Exon2: 48 residues, 233112945-233113085Exon3: 17 residues, 233113334-233113379Exon4: 38 residues, 233113555-233113665Exon5: 54 residues, 233114327-233114483Exon6: 34 residues, 233115376-233115474Exon7: 69 residues, 233115835-233116036Exon8: 40 residues, 233116228-233116343Exon9: 40 residues, 233116538-233116653Exon10: 73 residues, 233117320-233117534Exon11: 45 residues, 233117725-233117856Exon12: 264 residues, 233118496-233119282Exon13: 2 residues, -Jump to ACHG_HUMAN  
Tune and view alternative isoforms
Loci Cluster (Details)Loci: 3220 233099165-233108448 ~-9K 22296(CHRND)(+)Loci: 3221 233112680-233119282 ~-7K 22297(CHRNG)(+)Loci: 4500 233339418-233349519 ~-10K 22308(KCNJ13)(-)Loci: 4499 233052780-233060782 ~-8K 22293(ECEL1)(-)Link out to UCSC