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0ACHE_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameCHRNE
DescriptionAcetylcholine receptor protein, epsilon subunit precursor.
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005892 nicotinic acetylcholine-gated receptor-chan... (TAS)
0015464 acetylcholine receptor activity (TAS)
0008324 cation transporter activity (TAS)
0004889 nicotinic acetylcholine-activated cation-se... (TAS)
0006936 muscle contraction (TAS)
0007165 signal transduction (TAS)
0007271 synaptic transmission, cholinergic (TAS)
0006810 transport (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains assigned to SynO:
Neurotransmitter ligand-gated ion channels are transmembrane receptor-ion channel complexes that open transiently upon binding of specific ligands.llowing rapid transmission of signals at chemical synapses .Of the five families known.our have been shown to form a sequence-related superfamily. These are the gamma-aminobutyric acid type A (GABA-A).icotinic acetylcholine.lycine and the serotonin 5HT3 receptors. The ionotropic glutamate receptors () have a distinct primary structure.However.ll these receptors possess a pentameric structure (made up of varying subunits).urrounding a central pore. Each of these subunits contains a large extracellular N-terminal ligand-binding region; 3 hydrophobic transmembrane domains; a large intracellular region; and a fourth hydrophobic domain .This domain represents four transmembrane helices of a variety of neurotransmitter-gated ion-channels.
  IPR006029:Neurotransmitter-gated ion-channel transmembrane region
Neurotransmitter ligand-gated ion channels are transmembrane receptor-ion channel complexes that open transiently upon binding of specific ligands.llowing rapid transmission of signals at chemical synapses .Of the five families known.our have been shown to form a sequence-related superfamily. These are the gamma-aminobutyric acid type A (GABA-A).icotinic acetylcholine.lycine and the serotonin 5HT3 receptors. The ionotropic glutamate receptors () have a distinct primary structure.However.ll these receptors possess a pentameric structure (made up of varying subunits).urrounding a central pore. Each of these subunits contains a large extracellular N-terminal ligand-binding region; 3 hydrophobic transmembrane domains; a large intracellular region; and a fourth hydrophobic domain .This InterPro entry represents the GABA-A.icotinic.lycine.nd 5HT3 receptors.
  IPR006201:Neurotransmitter-gated ion-channel
InterPro domains unassigned to SynO:
Neurotransmitter ligand-gated ion channels are transmembrane receptor-ion channel complexes that open transiently upon binding of specific ligands.llowing rapid transmission of signals at chemical synapses .Of the five families known.our have been shown to form a sequence-related superfamily. These are the gamma-aminobutyric acid type A (GABA-A).icotinic acetylcholine.lycine and the serotonin 5HT3 receptors. The ionotropic glutamate receptors () have a distinct primary structure.However.ll these receptors possess a pentameric structure (made up of varying subunits).urrounding a central pore. Each of these subunits contains a large extracellular N-terminal ligand-binding region; 3 hydrophobic transmembrane domains; a large intracellular region; and a fourth hydrophobic domain .Nicotinic acetylcholine receptors are ligand-gated ion channels that mediate signaltransduction at the post-synaptic membrane of cholinergic synapses.uch asthe neuromuscular junction . They belong to a family of neurotransmitter-gated receptors.ncluding glycine.amma-aminobutyric-acid (GABA).erotonin 5HT3 receptors. These are oligomeric transmembrane(TM) complexes (pentamers of 2 alpha and 1 beta. gamma and 1 deltasubunit) that contain a central channel.hich transiently opens upon binding of a specific neurotransmitters. Their sequences are related and share the same topology: each hasan extracellular.lycosylated N-terminal ligand-binding domain; 3 hydrophobic TM regions.hich form the channel; a hydrophilic cytoplasmicdomain; followed by a fourth putative TM region . The nicotinic receptor ligand binding domain is a specialized pocket of aromatic and hydrophobic residues formed at interfaces between protein subunits that changes conformation to convert agonist binding into gating of an intrinsic ion channel . The expression of acetylcholine receptors is activated during muscledifferentiation and upon denervation of adult muscle . Receptor functionis regulated by phosphorylation and dephosphorylation by kinases andphosphatases present in the post-synaptic membranes . Most of thephosphorylation sites are located in the major intracellular loop betweenthe third and fourth TM regions and are closely spaced.
  IPR002394:Nicotinic acetylcholine receptor
Neurotransmitter ligand-gated ion channels are transmembrane receptor-ion channel complexes that open transiently upon binding of specific ligands.llowing rapid transmission of signals at chemical synapses .Of the five families known.our have been shown to form a sequence-related superfamily. These are the gamma-aminobutyric acid type A (GABA-A).icotinic acetylcholine.lycine and the serotonin 5HT3 receptors. The ionotropic glutamate receptors () have a distinct primary structure.However.ll these receptors possess a pentameric structure (made up of varying subunits).urrounding a central pore. Each of these subunits contains a large extracellular N-terminal ligand-binding region; 3 hydrophobic transmembrane domains; a large intracellular region; and a fourth hydrophobic domain .This entry presents the extracellular ligand binding domain of these ion channels. This domain forms a pentameric arrangement in the known structure.
  IPR006202:Neurotransmitter-gated ion-channel ligand-binding
IPR006202:Neur_chan_LBD 
Evalue:-92.5850296020508 
Location:24-240IPR006029:Neur_chan_memb 
Evalue:-85.0362091064453 
Location:247-474
SequencesProtein: ACHE_HUMAN (493 aa)
mRNA: NM_000080
Local Annotation
Synapse Ontology
this kind of receptor usually locates at the postsynaptic plasma membranous region.
sdb:0109 ionotropic receptor  (Evidence:domains)
priming for exocytosis prepares the calcium-dependent release and may involve partial fusion process. The vesicles are primed and become responsive to calcium.
sdb:0120 priming  (Evidence:domains)
?
sdb:0305 binding to postsynaptic receptor and internization  (Evidence:domains)
KO assignmentK04817
  Level 3 annotation:
    cholinergic receptor, nicotinic, epsilon polypeptide
  Level 2 annotation:
    Ion channels
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 376 residues, 4741839-4742965Exon2: 37 residues, 4743074-4743181Exon3: 64 residues, 4743271-4743458Exon4: 40 residues, 4743541-4743656Exon5: 40 residues, 4744866-4744981Exon6: 69 residues, 4745063-4745264Exon7: 35 residues, 4745598-4745699Exon8: 54 residues, 4746005-4746161Exon9: 38 residues, 4746290-4746400Exon10: 17 residues, 4746523-4746568Exon11: 49 residues, 4746694-4746837Exon12: 21 residues, 4747091-4747148Exon13: 2 residues, -Jump to ACHE_HUMAN  
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Loci Cluster (Details)Loci: 2970 4657391-4673694 ~-16K 14928(PLD2)(+)Loci: 4256 4741839-4747148 ~-5K 14931(CHRNE)(-)Loci: 4257 4781348-4784063 ~-3K 14933(SLC25A11)(-)Loci: 2971 4841999-4868720 ~-27K 14947(KIF1C)(+)Loci: 2972 5126316-5227430 ~-101K 14961(RABEP1)(+)Loci: 4255 4583578-4589863 ~-6K 14918(CXCL16)(-)Link out to UCSC