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0ACHB2_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameCHRNB2
DescriptionNeuronal acetylcholine receptor protein, beta-2 subunit precursor.
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005892 nicotinic acetylcholine-gated receptor-chan... (TAS)
0015464 acetylcholine receptor activity (TAS)
0004889 nicotinic acetylcholine-activated cation-se... (TAS)
0007165 signal transduction (TAS)
0006810 transport (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains assigned to SynO:
Neurotransmitter ligand-gated ion channels are transmembrane receptor-ion channel complexes that open transiently upon binding of specific ligands.llowing rapid transmission of signals at chemical synapses .Of the five families known.our have been shown to form a sequence-related superfamily. These are the gamma-aminobutyric acid type A (GABA-A).icotinic acetylcholine.lycine and the serotonin 5HT3 receptors. The ionotropic glutamate receptors () have a distinct primary structure.However.ll these receptors possess a pentameric structure (made up of varying subunits).urrounding a central pore. Each of these subunits contains a large extracellular N-terminal ligand-binding region; 3 hydrophobic transmembrane domains; a large intracellular region; and a fourth hydrophobic domain .This domain represents four transmembrane helices of a variety of neurotransmitter-gated ion-channels.
  IPR006029:Neurotransmitter-gated ion-channel transmembrane region
Neurotransmitter ligand-gated ion channels are transmembrane receptor-ion channel complexes that open transiently upon binding of specific ligands.llowing rapid transmission of signals at chemical synapses .Of the five families known.our have been shown to form a sequence-related superfamily. These are the gamma-aminobutyric acid type A (GABA-A).icotinic acetylcholine.lycine and the serotonin 5HT3 receptors. The ionotropic glutamate receptors () have a distinct primary structure.However.ll these receptors possess a pentameric structure (made up of varying subunits).urrounding a central pore. Each of these subunits contains a large extracellular N-terminal ligand-binding region; 3 hydrophobic transmembrane domains; a large intracellular region; and a fourth hydrophobic domain .This InterPro entry represents the GABA-A.icotinic.lycine.nd 5HT3 receptors.
  IPR006201:Neurotransmitter-gated ion-channel
InterPro domains unassigned to SynO:
Neurotransmitter ligand-gated ion channels are transmembrane receptor-ion channel complexes that open transiently upon binding of specific ligands.llowing rapid transmission of signals at chemical synapses .Of the five families known.our have been shown to form a sequence-related superfamily. These are the gamma-aminobutyric acid type A (GABA-A).icotinic acetylcholine.lycine and the serotonin 5HT3 receptors. The ionotropic glutamate receptors () have a distinct primary structure.However.ll these receptors possess a pentameric structure (made up of varying subunits).urrounding a central pore. Each of these subunits contains a large extracellular N-terminal ligand-binding region; 3 hydrophobic transmembrane domains; a large intracellular region; and a fourth hydrophobic domain .Nicotinic acetylcholine receptors are ligand-gated ion channels that mediate signaltransduction at the post-synaptic membrane of cholinergic synapses.uch asthe neuromuscular junction . They belong to a family of neurotransmitter-gated receptors.ncluding glycine.amma-aminobutyric-acid (GABA).erotonin 5HT3 receptors. These are oligomeric transmembrane(TM) complexes (pentamers of 2 alpha and 1 beta. gamma and 1 deltasubunit) that contain a central channel.hich transiently opens upon binding of a specific neurotransmitters. Their sequences are related and share the same topology: each hasan extracellular.lycosylated N-terminal ligand-binding domain; 3 hydrophobic TM regions.hich form the channel; a hydrophilic cytoplasmicdomain; followed by a fourth putative TM region . The nicotinic receptor ligand binding domain is a specialized pocket of aromatic and hydrophobic residues formed at interfaces between protein subunits that changes conformation to convert agonist binding into gating of an intrinsic ion channel . The expression of acetylcholine receptors is activated during muscledifferentiation and upon denervation of adult muscle . Receptor functionis regulated by phosphorylation and dephosphorylation by kinases andphosphatases present in the post-synaptic membranes . Most of thephosphorylation sites are located in the major intracellular loop betweenthe third and fourth TM regions and are closely spaced.
  IPR002394:Nicotinic acetylcholine receptor
Neurotransmitter ligand-gated ion channels are transmembrane receptor-ion channel complexes that open transiently upon binding of specific ligands.llowing rapid transmission of signals at chemical synapses .Of the five families known.our have been shown to form a sequence-related superfamily. These are the gamma-aminobutyric acid type A (GABA-A).icotinic acetylcholine.lycine and the serotonin 5HT3 receptors. The ionotropic glutamate receptors () have a distinct primary structure.However.ll these receptors possess a pentameric structure (made up of varying subunits).urrounding a central pore. Each of these subunits contains a large extracellular N-terminal ligand-binding region; 3 hydrophobic transmembrane domains; a large intracellular region; and a fourth hydrophobic domain .This entry presents the extracellular ligand binding domain of these ion channels. This domain forms a pentameric arrangement in the known structure.
  IPR006202:Neurotransmitter-gated ion-channel ligand-binding
IPR006029:Neur_chan_memb 
Evalue:-113.443695068359 
Location:241-478IPR006202:Neur_chan_LBD 
Evalue:-112.677780151367 
Location:29-234
SequencesProtein: ACHB2_HUMAN (502 aa)
mRNA: NM_000748
Local Annotation
Synapse Ontology
Postsynaptic compartment is represented by a patch of plasma membrane containing a packed array of neurotransmitter receptors and by an underlying dense matrix, the postsynaptic density (PSD).
sdb:0005 Postsynaptic compartment  (Evidence:keywords,domains)
this kind of receptor usually locates at the postsynaptic plasma membranous region.
sdb:0109 ionotropic receptor  (Evidence:keywords,domains)
priming for exocytosis prepares the calcium-dependent release and may involve partial fusion process. The vesicles are primed and become responsive to calcium.
sdb:0120 priming  (Evidence:keywords,domains)
?
sdb:0305 binding to postsynaptic receptor and internization  (Evidence:keywords,domains)
KO assignmentK04813
  Level 3 annotation:
    cholinergic receptor, nicotinic, beta polypeptide 2 (neuronal)
  Level 2 annotation:
    Ion channels
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 110 residues, 152806880-152807208Exon2: 50 residues, 152808561-152808707Exon3: 17 residues, 152808891-152808936Exon4: 38 residues, 152809357-152809467Exon5: 326 residues, 152810288-152811261Exon6: 284 residues, 152814861-152815707Exon7: 2 residues, -Jump to ACHB2_HUMAN  
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Loci Cluster (Details)Loci: 3833 152220753-152225430 ~-5K 2681(RAB13)(-)Loci: 2551 152511662-152514973 ~-3K 2706(HAX1)(+)Loci: 2552 152806880-152815707 ~-9K 2720(CHRNB2)(+)Loci: 3834 152821158-152847306 ~-26K 2722(ADAR)(-)Loci: 3835 153201398-153209847 ~-8K 2739(SHC1)(-)Loci: 2553 153412983-153424069 ~-11K 2783(TRIM46)(+)Loci: 2554 153513997-153526262 ~-12K 2831(HCN3)(+)Loci: 3836 153526253-153537835 ~-12K 2833(PKLR)(-)Loci: 2555 153669594-153670676 ~-1K 2846(POU5FLC1)(+)Loci: 2556 154095923-154121459 ~-26K 2875(SYT11)(+)Loci: 3837 154183269-154214942 ~-32K 2882(ARHGEF2)(-)Loci: 2557 154297589-154306917 ~-9K 2890(RAB25)(+)Loci: 2558 154362603-154374280 ~-12K 2897(+)Loci: 2559 154855709-154862142 ~-6K 2944(HAPLN2)(+)Loci: 2560 154878363-154895942 ~-18K 2945(BCAN)(+)Loci: 3838 154905181-154913813 ~-9K 2947(NES)(-)Loci: 2561 155097294-155118266 ~-21K 2961(NTRK1)(+)Loci: 3839 155171256-155281786 ~-111K 2965(ARHGEF11)(-)Loci: 2550 151897823-151900928 ~-3K 2658(SNAPAP)(+)Link out to UCSC