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0ACHA4_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameCHRNA4
DescriptionNeuronal acetylcholine receptor protein, alpha-4 subunit precursor.
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005892 nicotinic acetylcholine-gated receptor-chan... (TAS)
0015464 acetylcholine receptor activity (TAS)
0004889 nicotinic acetylcholine-activated cation-se... (TAS)
0007399 neurogenesis (TAS)
0007165 signal transduction (TAS)
0007268 synaptic transmission (TAS)
0006810 transport (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains assigned to SynO:
Neurotransmitter ligand-gated ion channels are transmembrane receptor-ion channel complexes that open transiently upon binding of specific ligands.llowing rapid transmission of signals at chemical synapses .Of the five families known.our have been shown to form a sequence-related superfamily. These are the gamma-aminobutyric acid type A (GABA-A).icotinic acetylcholine.lycine and the serotonin 5HT3 receptors. The ionotropic glutamate receptors () have a distinct primary structure.However.ll these receptors possess a pentameric structure (made up of varying subunits).urrounding a central pore. Each of these subunits contains a large extracellular N-terminal ligand-binding region; 3 hydrophobic transmembrane domains; a large intracellular region; and a fourth hydrophobic domain .This domain represents four transmembrane helices of a variety of neurotransmitter-gated ion-channels.
  IPR006029:Neurotransmitter-gated ion-channel transmembrane region
Neurotransmitter ligand-gated ion channels are transmembrane receptor-ion channel complexes that open transiently upon binding of specific ligands.llowing rapid transmission of signals at chemical synapses .Of the five families known.our have been shown to form a sequence-related superfamily. These are the gamma-aminobutyric acid type A (GABA-A).icotinic acetylcholine.lycine and the serotonin 5HT3 receptors. The ionotropic glutamate receptors () have a distinct primary structure.However.ll these receptors possess a pentameric structure (made up of varying subunits).urrounding a central pore. Each of these subunits contains a large extracellular N-terminal ligand-binding region; 3 hydrophobic transmembrane domains; a large intracellular region; and a fourth hydrophobic domain .This InterPro entry represents the GABA-A.icotinic.lycine.nd 5HT3 receptors.
  IPR006201:Neurotransmitter-gated ion-channel
InterPro domains unassigned to SynO:
Neurotransmitter ligand-gated ion channels are transmembrane receptor-ion channel complexes that open transiently upon binding of specific ligands.llowing rapid transmission of signals at chemical synapses .Of the five families known.our have been shown to form a sequence-related superfamily. These are the gamma-aminobutyric acid type A (GABA-A).icotinic acetylcholine.lycine and the serotonin 5HT3 receptors. The ionotropic glutamate receptors () have a distinct primary structure.However.ll these receptors possess a pentameric structure (made up of varying subunits).urrounding a central pore. Each of these subunits contains a large extracellular N-terminal ligand-binding region; 3 hydrophobic transmembrane domains; a large intracellular region; and a fourth hydrophobic domain .Nicotinic acetylcholine receptors are ligand-gated ion channels that mediate signaltransduction at the post-synaptic membrane of cholinergic synapses.uch asthe neuromuscular junction . They belong to a family of neurotransmitter-gated receptors.ncluding glycine.amma-aminobutyric-acid (GABA).erotonin 5HT3 receptors. These are oligomeric transmembrane(TM) complexes (pentamers of 2 alpha and 1 beta. gamma and 1 deltasubunit) that contain a central channel.hich transiently opens upon binding of a specific neurotransmitters. Their sequences are related and share the same topology: each hasan extracellular.lycosylated N-terminal ligand-binding domain; 3 hydrophobic TM regions.hich form the channel; a hydrophilic cytoplasmicdomain; followed by a fourth putative TM region . The nicotinic receptor ligand binding domain is a specialized pocket of aromatic and hydrophobic residues formed at interfaces between protein subunits that changes conformation to convert agonist binding into gating of an intrinsic ion channel . The expression of acetylcholine receptors is activated during muscledifferentiation and upon denervation of adult muscle . Receptor functionis regulated by phosphorylation and dephosphorylation by kinases andphosphatases present in the post-synaptic membranes . Most of thephosphorylation sites are located in the major intracellular loop betweenthe third and fourth TM regions and are closely spaced.
  IPR002394:Nicotinic acetylcholine receptor
Neurotransmitter ligand-gated ion channels are transmembrane receptor-ion channel complexes that open transiently upon binding of specific ligands.llowing rapid transmission of signals at chemical synapses .Of the five families known.our have been shown to form a sequence-related superfamily. These are the gamma-aminobutyric acid type A (GABA-A).icotinic acetylcholine.lycine and the serotonin 5HT3 receptors. The ionotropic glutamate receptors () have a distinct primary structure.However.ll these receptors possess a pentameric structure (made up of varying subunits).urrounding a central pore. Each of these subunits contains a large extracellular N-terminal ligand-binding region; 3 hydrophobic transmembrane domains; a large intracellular region; and a fourth hydrophobic domain .This entry presents the extracellular ligand binding domain of these ion channels. This domain forms a pentameric arrangement in the known structure.
  IPR006202:Neurotransmitter-gated ion-channel ligand-binding
IPR006029:Neur_chan_memb 
Evalue:-121.744728088379 
Location:250-618IPR006202:Neur_chan_LBD 
Evalue:-117.346786499023 
Location:37-243
SequencesProtein: ACHA4_HUMAN (627 aa)
mRNA: BC096290 BC096293
Local Annotation
Synapse Ontology
Postsynaptic compartment is represented by a patch of plasma membrane containing a packed array of neurotransmitter receptors and by an underlying dense matrix, the postsynaptic density (PSD).
sdb:0005 Postsynaptic compartment  (Evidence:keywords,domains)
this kind of receptor usually locates at the postsynaptic plasma membranous region.
sdb:0109 ionotropic receptor  (Evidence:keywords,domains)
priming for exocytosis prepares the calcium-dependent release and may involve partial fusion process. The vesicles are primed and become responsive to calcium.
sdb:0120 priming  (Evidence:keywords,domains)
?
sdb:0305 binding to postsynaptic receptor and internization  (Evidence:keywords,domains)
KO assignmentK04806
  Level 3 annotation:
    cholinergic receptor, nicotinic, alpha polypeptide 4
  Level 2 annotation:
    Ion channels
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 91 residues, 61448389-61448659Exon2: 460 residues, 61451448-61452823Exon3: 47 residues, 61457770-61457905Exon4: 17 residues, 61458166-61458211Exon5: 52 residues, 61461343-61461495Exon6: 73 residues, 61462885-61463100Exon7: 2 residues, -Jump to ACHA4_HUMANExon1: 91 residues, 61448389-61448659Exon2: 460 residues, 61451448-61452823Exon3: 38 residues, 61457770-61457880Exon4: 17 residues, 61458166-61458211Exon5: 52 residues, 61461343-61461495Exon6: 73 residues, 61462885-61463100Exon7: 2 residues, -Jump to ACHA4_HUMAN  
Tune and view alternative isoforms
Loci Cluster (Details)Loci: 3279 60906621-60915796 ~-9K 23505(OGFR)(+)Loci: 3280 61337720-61342298 ~-5K 23526(BIRC7)(+)Loci: 4537 61448389-61463100 ~-15K 23536(CHRNA4)(-)Loci: 4538 61507985-61574437 ~-66K 23542(KCNQ2)(-)Loci: 4539 61630221-61639151 ~-9K 23549(PTK6)(-)Loci: 4540 61642606-61649301 ~-7K 23550(SRMS)(-)Loci: 4541 61659883-61676033 ~-16K 23552(PRIC285)(-)Loci: 4542 61689398-61721673 ~-32K 23556(GMEB2)(-)Loci: 3281 61996961-62035838 ~-39K 23585(DNAJC5)(+)Loci: 3282 62082900-62134895 ~-52K 23593(C20orf14)(+)Loci: 3283 62181931-62202435 ~-21K 23600(OPRL1)(+)Loci: 3278 60810633-60864567 ~-54K 23503(NTSR1)(+)Link out to UCSC