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0ACCN4_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
DescriptionAmiloride-sensitive cation channel 4 (amiloride-sensitive cation channel 4, pituitary) (acid sensing ion channel 4).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
Domain Architecture (Details)
InterPro domains unassigned to SynO:
The apical membrane of many tight epithelia contains sodium channels thatare primarily characterised by their high affinity to the diuretic blockeramiloride . These channels mediate the first step of active sodiumreabsorption essential for the maintenance of body salt and waterhomeostasis . In vertebrates.he channels control reabsorption ofsodium in kidney.olon.ung and sweat glands; they also play a role intaste perception.Members of the epithelial Na+ channel (ENaC) family fall into foursubfamilies.ermed alpha.eta.amma and delta . The proteins exhibitthe same apparent topology.ach with two transmembrane (TM) spanningsegments.eparated by a large extracellular loop. In most ENaC proteinsstudied to date.he extracellular domains are highly conserved and containnumerous cysteine residues.ith flanking C-terminal amphipathic TM regions.ostulated to contribute to the formation of the hydrophilic pores of theoligomeric channel protein complexes. It is thought that the well-conservedextracellular domains serve as receptors to control the activities of thechannels.Vertebrate ENaC proteins are similar to degenerins of Caenorhabditis elegans: and unc-8. These proteins can be mutated to cause neuronal degradation.nd are also thought to form sodium channels.Structurally.he proteins that belong to this family consist of about 510to 920 amino acid residues. They are made of an intracellular N-terminusregion followed by a transmembrane domain. large extracellular loop.second transmembrane segment and a C-terminal intracellular tail .
  IPR001873:Na+ channel, amiloride-sensitive
SequencesProtein: ACCN4_HUMAN (647 aa)
mRNA: NM_018674 NM_182847
Local Annotation
Synapse Ontology
Na channel plays an important role in the course of action potential.
sdb:0287 Na channel  (Evidence:keywords)
KO assignmentK04831
  Level 3 annotation:
    amiloride-sensitive cation channel 4, pituitary
  Level 2 annotation:
    Ion channels
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 326 residues, 220087295-220088272Exon2: 50 residues, 220104723-220104868Exon3: 44 residues, 220104966-220105094Exon4: 56 residues, 220105280-220105443Exon5: 21 residues, 220105848-220105905Exon6: 53 residues, 220108136-220108290Exon7: 32 residues, 220110031-220110123Exon8: 28 residues, 220110207-220110287Exon9: 37 residues, 220110597-220110702Exon10: 280 residues, 220110898-220111732Exon11: 2 residues, -Jump to ACCN4_HUMANExon1: 326 residues, 220087295-220088272Exon2: 50 residues, 220104723-220104868Exon3: 44 residues, 220104966-220105094Exon4: 56 residues, 220105280-220105443Exon5: 53 residues, 220108136-220108290Exon6: 32 residues, 220110031-220110123Exon7: 28 residues, 220110207-220110287Exon8: 37 residues, 220110597-220110702Exon9: 280 residues, 220110898-220111732Exon10: 2 residues, -Jump to ACCN4_HUMAN  
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Loci Cluster (Details)Loci: 3213 219232701-219236409 ~-4K 22084(BCS1L)(+)Loci: 3214 219354948-219388259 ~-33K 22089(CYP27A1)(+)Loci: 3215 219532641-219535120 ~-2K 22095(CDK5R2)(+)Loci: 4494 219782737-219791916 ~-9K 22116(ABCB6)(-)Loci: 3216 219991342-219999703 ~-8K 22140(DES)(+)Loci: 3217 220087295-220111732 ~-24K 22148(ACCN4)(+)Loci: 3218 220145197-220148671 ~-3K 22154(INHA)(+)Loci: 4493 219210885-219232599 ~-22K 22082(ZNF142)(-)Link out to UCSC