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0ABI2_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameABI2
DescriptionAbl-interactor 2 (abelson interactor 2) (abi-2) (abl-binding protein 3) (ablbp3) (arg-binding protein 1) (argbp1).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005737 cytoplasm (TAS)
0030175 filopodium (NAS)
0030027 lamellipodium (NAS)
0008093 cytoskeletal adaptor activity (TAS)
0003677 DNA binding (TAS)
0019900 kinase binding (NAS)
0017124 SH3 domain binding (TAS)
0005070 SH3/SH2 adaptor activity (TAS)
0008154 actin polymerization and/or depolymerization (NAS)
0016477 cell migration (TAS)
0007010 cytoskeleton organization and biogenesis (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
The region featured in this family is found towards the N-terminus of a number of adaptor proteins that interact with Abl-family tyrosine kinases . More specifically.t is termed the homeo-domain homologous region (HHR).s it is similar to the DNA-binding region of homeo-domain proteins . Other homeo-domain proteins have been implicated in specifying positional information during embryonic development.nd in the regulation of the expression of cell-type specific genes . The Abl-interactor proteins are thought to coordinate the cytoplasmic and nuclear functions of the Abl-family kinases.nd seem to be involved in cytoskeletal reorganisation.ut their precise role remains unclear .
  IPR012849:Abl-interactor, homeo-domain homologous region
Phagocytes form the first line of defence against invasion by micro-organisms. Engulfing of bacteria by neutrophils is accompanied by theconsumption of large amounts of oxygen - a so-called respiratory burst.Defects in phagocytosis involving the lack of a respiratory burst giverise to chronic granulomatous disease (CGD).n which patients are pre-disposed to infection.ften from otherwise non-pathogenic bacteria .Regulation of the respiratory burst takes place at the phagocytic vacuole.The process is mediated by NADPH oxidase.hich transports electrons acrossthe plasma membrane to form superoxide (an oxygen molecule with an extraelectron that is toxic to normal cells) in the vacuole interior. Theelectrons are carried across the membrane by a short electron transportchain in the form of an unusual flavocytochrome b .To conserve NADPH and avoid the toxic effects of superoxide.he oxidase remains inactive until it receives an appropriate stimulus. Activationinvolves the participation of a number of cytosolic proteins.ome of which attach to the flavocytochrome. P47phox.67phox and p40phox arespecialised components of phagocytic cells.ll of which contain SH3domains .y means of which they attach to proline-rich regions of otherproteins. Upon activation.47phox and p67phox are phosphorylated and.ith p40phox.ranslocate to the region of the plasma membrane formingthe phagocytic vacuole.here they associates with hydrophilic regionsof the flavocytochrome .
  IPR000108:Neutrophil cytosol factor 2
SH3 (src Homology-3) domains are small protein modules containing approximately 50 amino acid residues . They are found in a great variety of intracellular or membrane-associated proteins for example.n a variety of proteins with enzymatic activity.n adaptor proteins that lack catalytic sequences and in cytoskeletal proteins.uch as fodrin and yeast actin binding protein ABP-1. The SH3 domain has a characteristic fold which consists of five or six beta-strands arranged as two tightly packed anti-parallel beta sheets. The linker regions may contain short helices . The surface of the SH2-domain bears a flat.ydrophobic ligand-binding pocket which consists of three shallow grooves defined by conservative aromatic residues in which the ligand adopts an extended left-handed helical arrangement. The ligand binds with low affinity but this may be enhanced by multiple interactions.The region bound by the SH3 domain is in all cases proline-rich and contains PXXP as a core-conserved binding motif. The function of the SH3 domain is not well understood but they may mediate many diverse processes such as increasing local concentration of proteins.ltering their subcellular location and mediating the assembly of large multiprotein complexes .
  IPR001452:Src homology-3
IPR012849:Abi_HHR 
Evalue:-58.8239097595215 
Location:93-171IPR001452:SH3_1 
Evalue:-23.2839965820313 
Location:454-508IPR000108:P67PHOX 
Evalue:0 
Location:282-299
SequencesProtein: ABI2_HUMAN (513 aa)
mRNA: NM_005759
Local Annotation
Synapse Ontology
Various stages of the synaptic vesicle cycle, including attachment, prefusion, triggering, recycling and reloading of the vesicles with transmitter.
sdb:0098 synaptic vesicle cycling  (Evidence:keywords,domains)
attachment of the vesicle filled with transmitters involves a specific interaction between the vesicle membrane and the presynaptic active zone.
sdb:0148 docking  (Evidence:keywords,domains)
KO assignmentK05751
  Level 3 annotation:
    abl interactor 2
  Level 2 annotation:
    Regulation of actin cytoskeleton
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 65 residues, 203901406-203901599Exon2: 58 residues, 203939844-203940012Exon3: 61 residues, 203953175-203953352Exon4: 34 residues, 203964013-203964111Exon5: 51 residues, 203967667-203967814Exon6: 43 residues, 203968623-203968748Exon7: 55 residues, 203975543-203975702Exon8: 31 residues, 203984252-203984339Exon9: 60 residues, 203989875-203990049Exon10: 146 residues, 204000144-204000576Exon11: 2 residues, -Jump to ABI2_HUMAN  
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