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0AATC_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameGOT1
DescriptionAspartate aminotransferase, cytoplasmic (ec 2.6.1.1) (transaminase a) (glutamate oxaloacetate transaminase 1).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0006533 aspartate catabolism (TAS)
Domain Architecture (Details)
InterPro domains unassigned to SynO:
Aminotransferases share certain mechanistic features with other pyridoxal-phosphate dependent enzymes.uch as the covalent binding of the pyridoxal-phosphate group to a lysine residue. On the basis of sequence similarity.hese various enzymes can be grouped into class I and class II. This entry includes proteins from both subfamilies.
  IPR004839:Aminotransferase, class I and II
Aspartate aminotransferase is important for the metabolism of amino acids and Krebs-cycle related organic acids. In plants.t is involved in nitrogen metabolism and in aspects of carbon and energy metabolism. The enzyme catalyses the reaction:L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamateAminotransferases share certain mechanistic features with other pyridoxal-phosphate-dependent enzymes.uch as the covalent binding of the pyridoxal-phosphate group to a lysine residue . This family includes some aromatic-amino-acid aminotransferases too.
  IPR000796:Aspartate/other aminotransferase
IPR004839:Aminotran_1_2 
Evalue:-132.823913574219 
Location:30-404
SequencesProtein: AATC_HUMAN (412 aa)
mRNA: NM_002079
Local Annotation
Synapse Ontology
mitochondria are frequently observed in the vicinity of the synaptic vesicle clusters, in agreement with the ATP requirement of several steps of the vesicle cycle.
sdb:0118 mitochondria  (Evidence:keywords)
KO assignmentK00813
  Level 3 annotation:
    aspartate aminotransferase
  Level 2 annotation:
    Carbon fixation
    Glutamate metabolism
    Alanine and aspartate metabolism
    Cysteine metabolism
    Arginine and proline metabolism
    Tyrosine metabolism
    Phenylalanine metabolism
    Phenylalanine
     tyrosine and tryptophan biosynthesis
    Alkaloid biosynthesis I
    Novobiocin biosynthesis
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 273 residues, 101146617-101147433Exon2: 49 residues, 101152326-101152469Exon3: 57 residues, 101153215-101153381Exon4: 52 residues, 101153470-101153621Exon5: 37 residues, 101155502-101155607Exon6: 39 residues, 101155883-101155996Exon7: 43 residues, 101156472-101156596Exon8: 62 residues, 101170370-101170552Exon9: 49 residues, 101180194-101180336Exon10: 2 residues, -Jump to AATC_HUMAN  
Tune and view alternative isoforms
Loci Cluster (Details)Loci: 3916 101461595-101481890 ~-20K 5514(COX15)(-)Loci: 2628 101532562-101601571 ~-69K 5517(ABCC2)(+)Loci: 3917 101625324-101759666 ~-134K 5519(DNMBP)(-)Loci: 2629 102096761-102114577 ~-18K 5532(SCD)(+)Loci: 3918 102273487-102279626 ~-6K 5541(NDUFB8)(-)Loci: 3919 102727568-102737262 ~-10K 5557(MRPL43)(-)Loci: 3915 101146617-101180336 ~-34K 5507(GOT1)(-)Link out to UCSC