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0AAPK1_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NamePRKAA1
Description5'-amp-activated protein kinase, catalytic alpha-1 chain (ec 2.7.1.-) (ampk alpha-1 chain).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005622 intracellular (IC)
0004691 cAMP-dependent protein kinase activity (NAS)
0042557 eukaryotic elongation factor-2 kinase activ... (ISS)
0004672 protein kinase activity (TAS)
0000187 activation of MAPK activity (NAS)
0046318 negative regulation of glucosylceramide bio... (NAS)
0017148 negative regulation of protein biosynthesis (ISS)
0045768 positive regulation of anti-apoptosis (NAS)
0045542 positive regulation of cholesterol biosynth... (NAS)
0046321 positive regulation of fatty acid oxidation (ISS)
0045722 positive regulation of gluconeogenesis (ISS)
0046326 positive regulation of glucose import (ISS)
0006468 protein amino acid phosphorylation (ISS)
0001666 response to hypoxia (NAS)
0007165 signal transduction (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
Eukaryotic protein kinases are enzymesthat belong to a very extensive family of proteins which share a conserved catalytic core common withboth serine/threonine and tyrosine protein kinases. There are a number of conserved regions in thecatalytic domain of protein kinases. In the N-terminal extremity of the catalytic domain there is aglycine-rich stretch of residues in the vicinity of a lysine residue.hich has been shown to be involvedin ATP binding. In the central part of the catalytic domain there is a conserved aspartic acid residuewhich is important for the catalytic activity of the enzyme . CAUTION: Despite SMART having created two different HMMs for Serine/Threonine protein kinase and for Tyrosine protein kinase.arge number of proteins match both signatures.s SMART considers it to be natural for these two closely related families.
  IPR002290:Serine/threonine protein kinase
Eukaryotic protein kinases are enzymesthat belong to a very extensive family of proteins which share a conserved catalytic core common withboth serine/threonine and tyrosine protein kinases. There are a number of conserved regions in thecatalytic domain of protein kinases. In the N-terminal extremity of the catalytic domain there is aglycine-rich stretch of residues in the vicinity of a lysine residue.hich has been shown to be involvedin ATP binding. In the central part of the catalytic domain there is a conserved aspartic acid residuewhich is important for the catalytic activity of the enzyme . This entry includes protein kinases from eukaryotes and viruses and may include some bacterial hits too.
  IPR000719:Protein kinase
Protein kinases () catalyze the phosphotransfer reaction fundamental to most signalling and regulatory processes in the eukaryotic cell . The catalytic subunit contains a core that is common to both serine/threonine and tyrosine protein kinases. The catalytic domain contains the nucleotide-binding site and the catalytic apparatus in an inter-lobe cleft. Structurally it shares functional and structural similarities with the ATP-grasp fold.hich is found in enzymes that catalyse the formation of an amide bond.nd with PIPK (phosphoinositol phosphate kinase). The three-dimensional fold of the protein kinase catalytic domain is similar to domains found in several other proteins. These include the catalytic domain of actin-fragmin kinase.n atypical protein kinase that regulates the F-actin capping activity in plasmodia ; the catalytic domain of phosphoinositide-3-kinase (PI3K).hich phosphorylates phosphoinositides and as such is involved in a number of fundamental cellular processes such as apoptosis.roliferation.otility and adhesion ; the catalytic domain of the MHCK/EF2 kinase.n atypical protein kinase that includes the TRP (transient channel potential) calcium-channel kinase involved in the modulation of calcium channels in eukaryotic cells in response to external signals ; choline kinase.hich catalyses the ATP-dependent phosphorylation of choline during the biosynthesis of phosphatidylcholine ; and 3.-aminoglycoside phosphotransferase type IIIa. bacterial enzyme that confers resistance to a range of aminoglycoside antibiotics .
  IPR011009:Protein kinase-like
IPR002290:S_TKc 
Evalue:-104.096910013008 
Location:18-270
SequencesProtein: AAPK1_HUMAN (550 aa)
mRNA: BC048980 NM_006251 NM_206907
Local Annotation
Synapse Ontology
transport of vesicles in the presynaptic neuron
sdb:0017 Mobilization: synapsins, CAM kinase I  (Evidence:keywords)
A process that increases long-term neuronal synaptic plasticity, the ability of neuronal synapses to change long-term as circumstances require. Long-term neuronal synaptic plasticity generally involves increase or decrease in actual synapse numbers.
sdb:0039 positive regulation of long-term neuronal synaptic plasticity  (Evidence:keywords)
A process that increases short-term neuronal synaptic plasticity, the ability of neuronal synapses to change in the short-term as circumstances require. Short-term neuronal synaptic plasticity generally involves increasing or decreasing synaptic sensitivity.
sdb:0043 positive regulation of short-term neuronal synaptic plasticity  (Evidence:keywords)
activation of protein kinase C
sdb:0206 activation of protein kinase C  (Evidence:keywords)
?
sdb:0265 cAMP mediated STP  (Evidence:keywords)
KO assignmentK07198
  Level 3 annotation:
    5'-AMP-activated protein kinase, catalytic alpha subunit
  Level 2 annotation:
    Insulin signaling pathway
    Adipocytokine signaling pathway
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 1215 residues, 40795238-40798881Exon2: 44 residues, 40800372-40800499Exon3: 164 residues, 40800610-40801097Exon4: 77 residues, 40803324-40803549Exon5: 31 residues, 40805274-40805362Exon6: 50 residues, 40807577-40807722Exon7: 17 residues, 40810786-40810831Exon8: 33 residues, 40811268-40811362Exon9: 49 residues, 40813303-40813445Exon10: 43 residues, 40833921-40834046Exon11: 2 residues, -Jump to AAPK1_HUMANExon1: 1215 residues, 40795238-40798881Exon2: 44 residues, 40800372-40800499Exon3: 164 residues, 40800610-40801097Exon4: 77 residues, 40803324-40803549Exon5: 31 residues, 40805274-40805362Exon6: 50 residues, 40807577-40807722Exon7: 33 residues, 40811268-40811362Exon8: 49 residues, 40813303-40813445Exon9: 43 residues, 40833921-40834046Exon10: 2 residues, -Jump to AAPK1_HUMANExon1: 83 residues, 40798634-40798881Exon2: 44 residues, 40800372-40800499Exon3: 164 residues, 40800610-40801097Exon4: 77 residues, 40803324-40803549Exon5: 31 residues, 40805274-40805362Exon6: 50 residues, 40807577-40807722Exon7: 17 residues, 40810786-40810831Exon8: 33 residues, 40811268-40811362Exon9: 49 residues, 40813303-40813445Exon10: 106 residues, 40833921-40834233Exon11: 2 residues, -Jump to AAPK1_HUMAN  
Tune and view alternative isoforms
Loci Cluster (Details)Loci: 4711 40795238-40834233 ~-39K 28748(PRKAA1)(-)Loci: 4710 40750335-40791767 ~-41K 28747(-)Link out to UCSC