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0AADAT_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameAADAT
DescriptionKynurenine/alpha-aminoadipate aminotransferase mitochondrial precursor (kat/aadat) (kynurenine--oxoglutarate transaminase ii) (ec 2.6.1.7) (kynurenine aminotransferase ii) (kynurenine--oxoglutarate aminotransferase ii) (2-aminoadipate transaminase) (ec 2.6.1.39) (2- aminoadipate aminotransferase) (alpha-aminoadipate aminotransferase) (aadat).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GON/A
Domain Architecture (Details)
InterPro domains unassigned to SynO:
Aminotransferases share certain mechanistic features with other pyridoxal-phosphate dependent enzymes.uch as the covalent binding of the pyridoxal-phosphate group to a lysine residue. On the basis of sequence similarity.hese various enzymes can be grouped into class I and class II. This entry includes proteins from both subfamilies.
  IPR004839:Aminotransferase, class I and II
IPR004839:Aminotran_1_2 
Evalue:-6.74472761154175 
Location:43-417
SequencesProtein: AADAT_HUMAN (425 aa)
mRNA: BC031068 NM_016228
Local Annotation
Synapse Ontology
mitochondria are frequently observed in the vicinity of the synaptic vesicle clusters, in agreement with the ATP requirement of several steps of the vesicle cycle.
sdb:0118 mitochondria  (Evidence:keywords)
KO assignmentK00816
  Level 3 annotation:
    kynurenine-oxoglutarate transaminase
  Level 2 annotation:
    Tryptophan metabolism
K00825
  Level 3 annotation:
    2-aminoadipate transaminase
  Level 2 annotation:
    Lysine biosynthesis
    Lysine degradation
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 250 residues, 171217948-171218695Exon2: 36 residues, 171219617-171219719Exon3: 37 residues, 171222444-171222551Exon4: 23 residues, 171224139-171224204Exon5: 22 residues, 171225052-171225114Exon6: 34 residues, 171226316-171226413Exon7: 29 residues, 171226873-171226956Exon8: 24 residues, 171228312-171228378Exon9: 72 residues, 171230861-171231071Exon10: 27 residues, 171236234-171236309Exon11: 46 residues, 171244841-171244974Exon12: 58 residues, 171246121-171246290Exon13: 138 residues, 171247349-171247758Exon14: 2 residues, -Jump to AADAT_HUMANExon1: 249 residues, 171217950-171218695Exon2: 36 residues, 171219617-171219719Exon3: 37 residues, 171222444-171222551Exon4: 23 residues, 171224139-171224204Exon5: 22 residues, 171225052-171225114Exon6: 34 residues, 171226316-171226413Exon7: 29 residues, 171226873-171226956Exon8: 24 residues, 171228312-171228378Exon9: 72 residues, 171230861-171231071Exon10: 27 residues, 171236234-171236309Exon11: 46 residues, 171244841-171244974Exon12: 58 residues, 171246121-171246290Exon13: 43 residues, 171247337-171247462Exon14: 25 residues, 171247869-171247940Exon15: 2 residues, -Jump to AADAT_HUMAN  
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Loci Cluster (Details)Loci: 4695 171217948-171247940 ~-30K 28408(AADAT)(-)Loci: 3439 170778296-170878732 ~-100K 28400(CLCN3)(+)Link out to UCSC