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0AA3R_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameADORA3
DescriptionAdenosine a3 receptor.
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005887 integral to plasma membrane (TAS)
0007190 adenylate cyclase activation (TAS)
0006954 inflammatory response (TAS)
0008016 regulation of heart contraction rate (TAS)
0007165 signal transduction (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains assigned to SynO:
G-protein-coupled receptors.PCRs.onstitute a vast protein family that encompasses a wide range of functions (including various autocrine.aracrine and endocrine processes). They show considerable diversity at the sequence level.n the basis of which they can be separated into distinct groups. We use the term clan to describe the GPCRs.s they embrace a group of families for which there are indications of evolutionary relationship.ut between which there is no statistically significant similarity in sequence . The currently known clan members include the rhodopsin-like GPCRs.he secretin-like GPCRs.he cAMP receptors.he fungal mating pheromone receptors.nd the metabotropic glutamate receptor family. There is a specialized database for GPCRs: http://www.gpcr.org/7tm/. The rhodopsin-like GPCRs themselves represent a widespread protein family that includes hormone.eurotransmitter and light receptors.ll of which transduce extracellular signals through interaction with guanine nucleotide-binding (G) proteins. Although their activating ligands vary widely in structure and character.he amino acid sequences of the receptors are very similar and are believed to adopt a common structural framework comprising 7transmembrane (TM) helices .In addition to their role in energy metabolism.urines (especiallyadenosine and adenine nucleotides) produce a wide range of pharmacologicaleffects mediated by activation of cell surface receptors . Distinctreceptors exist for adenosine. In the periphery.he main effects ofadenosine include vasodilation.ronchoconstriction.mmunosuppresion.nhibition of platelet aggregation.ardiac depression.timulation ofnociceptive afferents.nhibition of neurotransmitter release andinhibition of the release of other factors..g. hormones . In the CNS.denosine exerts a pre- and post-synaptic depressant action.educing motoractivity.epressing respiration.nducing sleep and relieving anxiety. Thephysiological role of adenosine is thought to be to adjust energy demandsin line with oxygen supply. Many of the clinical actions of methylxanthinesare thought to be mediated through antagonism of adenosine receptors. Foursubtypes of receptor have been identified.esignated A1.2A.2B and A3.
  IPR001634:Adenosine receptor
InterPro domains unassigned to SynO:
G-protein-coupled receptors.PCRs.onstitute a vast protein family that encompasses a wide range of functions (including various autocrine.aracrine and endocrine processes). They show considerable diversity at the sequence level.n the basis of which they can be separated into distinct groups. We use the term clan to describe the GPCRs.s they embrace a group of families for which there are indications of evolutionary relationship.ut between which there is no statistically significant similarity in sequence . The currently known clan members include the rhodopsin-like GPCRs.he secretin-like GPCRs.he cAMP receptors.he fungal mating pheromone receptors.nd the metabotropic glutamate receptor family. There is a specialized database for GPCRs: http://www.gpcr.org/7tm/. The rhodopsin-like GPCRs themselves represent a widespread protein family that includes hormone.eurotransmitter and light receptors.ll of which transduce extracellular signals through interaction with guanine nucleotide-binding (G) proteins. Although their activating ligands vary widely in structure and character.he amino acid sequences of the receptors are very similar and are believed to adopt a common structural framework comprising 7transmembrane (TM) helices .
  IPR000276:Rhodopsin-like GPCR superfamily
G-protein-coupled receptors.PCRs.onstitute a vast protein family that encompasses a wide range of functions (including various autocrine.aracrine and endocrine processes). They show considerable diversity at the sequence level.n the basis of which they can be separated into distinct groups. We use the term clan to describe the GPCRs.s they embrace a group of families for which there are indications of evolutionary relationship.ut between which there is no statistically significant similarity in sequence . The currently known clan members include the rhodopsin-like GPCRs.he secretin-like GPCRs.he cAMP receptors.he fungal mating pheromone receptors.nd the metabotropic glutamate receptor family. There is a specialized database for GPCRs: http://www.gpcr.org/7tm/. The rhodopsin-like GPCRs themselves represent a widespread protein family that includes hormone.eurotransmitter and light receptors.ll of which transduce extracellular signals through interaction with guanine nucleotide-binding (G) proteins. Although their activating ligands vary widely in structure and character.he amino acid sequences of the receptors are very similar and are believed to adopt a common structural framework comprising 7transmembrane (TM) helices .In addition to their role in energy metabolism.urines (especiallyadenosine and adenine nucleotides) produce a wide range of pharmacologicaleffects mediated by activation of cell surface receptors. Distinctreceptors exist for adenosine. In the periphery.he main effects ofadenosine include vasodilation.ronchoconstriction.mmunosuppresion.nhibition of platelet aggregation.ardiac depression.timulation ofnociceptive afferents.nhibition of neurotransmitter release andinhibition of the release of other factors..g. hormones . In the CNS.denosine exerts a pre- and post-synaptic depressant action.educing motoractivity.epressing respiration.nducing sleep and relieving anxiety. Thephysiological role of adenosine is thought to be to adjust energy demandsin line with oxygen supply. Many of the clinical actions of methylxanthinesare thought to be mediated through antagonism of adenosine receptors. Foursubtypes of receptor have been identified.esignated A1.2A.2B and A3.A3 receptors are found in high levels in the testis.nd in lower levels inthe lung.idney and heart. They are also found in low levels in regionsof the CNS (including the cerebral cortex.triatum and olfactory bulb). Thepresence in high levels in the testis has led to the suggestion that it mayplay a role in reproduction . The A3 receptor inhibits adenylyl cyclasethrough a pertussis-toxin-sensitive G-protein.robably belonging to theGi/Go class.
  IPR000466:Adenosine A3 receptor
IPR000276:7tm_1 
Evalue:-54.4685211181641 
Location:29-282IPR000466:ADENOSINEA3R 
Evalue:0 
Location:297-314IPR000466:ADENOSINEA3R 
Evalue:0 
Location:6-18
SequencesProtein: AA3R_HUMAN (318 aa)
mRNA: NM_000677
Local Annotation
Synapse Ontology
?
sdb:0219 GPCR mediated signaling  (Evidence:domains)
?
sdb:0305 binding to postsynaptic receptor and internization  (Evidence:domains)
KO assignmentK04268
  Level 3 annotation:
    adenosine A3 receptor
  Level 2 annotation:
    G-protein coupled receptors
    Neuroactive ligand-receptor interaction
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 375 residues, 111843577-111844701Exon2: 374 residues, 111847149-111848266Exon3: 2 residues, -Jump to AA3R_HUMAN  
Tune and view alternative isoforms
Loci Cluster (Details)Loci: 3819 111843577-111848266 ~-5K 2174(ADORA3)(-)Loci: 2538 111963927-112057623 ~-94K 2175(RAP1A)(+)Loci: 2539 112099776-112111721 ~-12K 2178(DDX20)(+)Loci: 3820 112119976-112333300 ~-213K 2180(KCND3)(-)Loci: 2537 111793265-111806046 ~-13K 2169(ATP5F1)(+)Link out to UCSC