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0AA2BR_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameADORA2B
DescriptionAdenosine a2b receptor.
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005887 integral to plasma membrane (TAS)
0000187 activation of MAPK activity (TAS)
0007190 adenylate cyclase activation (TAS)
0006968 cellular defense response (TAS)
0007588 excretion (TAS)
0007186 G-protein coupled receptor protein signalin... (TAS)
0007254 JNK cascade (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains assigned to SynO:
G-protein-coupled receptors.PCRs.onstitute a vast protein family that encompasses a wide range of functions (including various autocrine.aracrine and endocrine processes). They show considerable diversity at the sequence level.n the basis of which they can be separated into distinct groups. We use the term clan to describe the GPCRs.s they embrace a group of families for which there are indications of evolutionary relationship.ut between which there is no statistically significant similarity in sequence . The currently known clan members include the rhodopsin-like GPCRs.he secretin-like GPCRs.he cAMP receptors.he fungal mating pheromone receptors.nd the metabotropic glutamate receptor family. There is a specialized database for GPCRs: http://www.gpcr.org/7tm/. The rhodopsin-like GPCRs themselves represent a widespread protein family that includes hormone.eurotransmitter and light receptors.ll of which transduce extracellular signals through interaction with guanine nucleotide-binding (G) proteins. Although their activating ligands vary widely in structure and character.he amino acid sequences of the receptors are very similar and are believed to adopt a common structural framework comprising 7transmembrane (TM) helices .In addition to their role in energy metabolism.urines (especiallyadenosine and adenine nucleotides) produce a wide range of pharmacologicaleffects mediated by activation of cell surface receptors . Distinctreceptors exist for adenosine. In the periphery.he main effects ofadenosine include vasodilation.ronchoconstriction.mmunosuppresion.nhibition of platelet aggregation.ardiac depression.timulation ofnociceptive afferents.nhibition of neurotransmitter release andinhibition of the release of other factors..g. hormones . In the CNS.denosine exerts a pre- and post-synaptic depressant action.educing motoractivity.epressing respiration.nducing sleep and relieving anxiety. Thephysiological role of adenosine is thought to be to adjust energy demandsin line with oxygen supply. Many of the clinical actions of methylxanthinesare thought to be mediated through antagonism of adenosine receptors. Foursubtypes of receptor have been identified.esignated A1.2A.2B and A3.
  IPR001634:Adenosine receptor
InterPro domains unassigned to SynO:
G-protein-coupled receptors.PCRs.onstitute a vast protein family that encompasses a wide range of functions (including various autocrine.aracrine and endocrine processes). They show considerable diversity at the sequence level.n the basis of which they can be separated into distinct groups. We use the term clan to describe the GPCRs.s they embrace a group of families for which there are indications of evolutionary relationship.ut between which there is no statistically significant similarity in sequence . The currently known clan members include the rhodopsin-like GPCRs.he secretin-like GPCRs.he cAMP receptors.he fungal mating pheromone receptors.nd the metabotropic glutamate receptor family. There is a specialized database for GPCRs: http://www.gpcr.org/7tm/. The rhodopsin-like GPCRs themselves represent a widespread protein family that includes hormone.eurotransmitter and light receptors.ll of which transduce extracellular signals through interaction with guanine nucleotide-binding (G) proteins. Although their activating ligands vary widely in structure and character.he amino acid sequences of the receptors are very similar and are believed to adopt a common structural framework comprising 7transmembrane (TM) helices .
  IPR000276:Rhodopsin-like GPCR superfamily
G-protein-coupled receptors.PCRs.onstitute a vast protein family that encompasses a wide range of functions (including various autocrine.aracrine and endocrine processes). They show considerable diversity at the sequence level.n the basis of which they can be separated into distinct groups. We use the term clan to describe the GPCRs.s they embrace a group of families for which there are indications of evolutionary relationship.ut between which there is no statistically significant similarity in sequence . The currently known clan members include the rhodopsin-like GPCRs.he secretin-like GPCRs.he cAMP receptors.he fungal mating pheromone receptors.nd the metabotropic glutamate receptor family. There is a specialized database for GPCRs: http://www.gpcr.org/7tm/. The rhodopsin-like GPCRs themselves represent a widespread protein family that includes hormone.eurotransmitter and light receptors.ll of which transduce extracellular signals through interaction with guanine nucleotide-binding (G) proteins. Although their activating ligands vary widely in structure and character.he amino acid sequences of the receptors are very similar and are believed to adopt a common structural framework comprising 7transmembrane (TM) helices .In addition to their role in energy metabolism.urines (especiallyadenosine and adenine nucleotides) produce a wide range of pharmacologicaleffects mediated by activation of cell surface receptors . Distinctreceptors exist for adenosine. In the periphery.he main effects ofadenosine include vasodilation.ronchoconstriction.mmunosuppresion.nhibition of platelet aggregation.ardiac depression.timulation ofnociceptive afferents.nhibition of neurotransmitter release andinhibition of the release of other factors..g. hormones. In the CNS.denosine exerts a pre- and post-synaptic depressant action.educing motoractivity.epressing respiration.nducing sleep and relieving anxiety. Thephysiological role of adenosine is thought to be to adjust energy demandsin line with oxygen supply. Many of the clinical actions of methylxanthinesare thought to be mediated through antagonism of adenosine receptors. Foursubtypes of receptor have been identified.esignated A1.2A.2B and A3.A2B receptors are widespread in the human brain relative to A2A receptors.By contrast.owever.n the rat its mRNA is found only in low levels inthe brain and it has a unique distribution in the periphery.igh levelsoccurring in the intestine and bladder . The receptor stimulates cAMPthrough G proteins.
  IPR001435:Adenosine A2B receptor
IPR000276:7tm_1 
Evalue:-65.958610534668 
Location:24-290IPR001435:ADENOSINA2BR 
Evalue:0 
Location:306-325IPR001634:ADENOSINER 
Evalue:0 
Location:8-17
SequencesProtein: AA2BR_HUMAN (332 aa)
mRNA: NM_000676
Local Annotation
Synapse Ontology
?
sdb:0219 GPCR mediated signaling  (Evidence:domains)
?
sdb:0305 binding to postsynaptic receptor and internization  (Evidence:domains)
KO assignmentK04267
  Level 3 annotation:
    adenosine A2b receptor
  Level 2 annotation:
    Calcium signaling pathway
    G-protein coupled receptors
    Neuroactive ligand-receptor interaction
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 223 residues, 15788955-15789622Exon2: 408 residues, 15818717-15819935Exon3: 2 residues, -Jump to AA2BR_HUMAN  
Tune and view alternative isoforms
Loci Cluster (Details)Loci: 2986 16259612-16281040 ~-21K 15219(TRPV2)(+)Loci: 2985 15788955-15819935 ~-31K 15203(ADORA2B)(+)Link out to UCSC