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0AA2AR_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameADORA2A
DescriptionAdenosine a2a receptor.
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005887 integral to plasma membrane (TAS)
0005624 membrane fraction (TAS)
0005886 plasma membrane (TAS)
0006915 apoptosis (TAS)
0007596 blood coagulation (TAS)
0006171 cAMP biosynthesis (TAS)
0007267 cell-cell signaling (TAS)
0006968 cellular defense response (TAS)
0007417 central nervous system development (TAS)
0008015 circulation (TAS)
0007188 G-protein signaling, coupled to cAMP nucleo... (TAS)
0006954 inflammatory response (TAS)
0006909 phagocytosis (TAS)
0007600 sensory perception (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains assigned to SynO:
G-protein-coupled receptors.PCRs.onstitute a vast protein family that encompasses a wide range of functions (including various autocrine.aracrine and endocrine processes). They show considerable diversity at the sequence level.n the basis of which they can be separated into distinct groups. We use the term clan to describe the GPCRs.s they embrace a group of families for which there are indications of evolutionary relationship.ut between which there is no statistically significant similarity in sequence . The currently known clan members include the rhodopsin-like GPCRs.he secretin-like GPCRs.he cAMP receptors.he fungal mating pheromone receptors.nd the metabotropic glutamate receptor family. There is a specialized database for GPCRs: http://www.gpcr.org/7tm/. The rhodopsin-like GPCRs themselves represent a widespread protein family that includes hormone.eurotransmitter and light receptors.ll of which transduce extracellular signals through interaction with guanine nucleotide-binding (G) proteins. Although their activating ligands vary widely in structure and character.he amino acid sequences of the receptors are very similar and are believed to adopt a common structural framework comprising 7transmembrane (TM) helices .In addition to their role in energy metabolism.urines (especiallyadenosine and adenine nucleotides) produce a wide range of pharmacologicaleffects mediated by activation of cell surface receptors . Distinctreceptors exist for adenosine. In the periphery.he main effects ofadenosine include vasodilation.ronchoconstriction.mmunosuppresion.nhibition of platelet aggregation.ardiac depression.timulation ofnociceptive afferents.nhibition of neurotransmitter release andinhibition of the release of other factors..g. hormones . In the CNS.denosine exerts a pre- and post-synaptic depressant action.educing motoractivity.epressing respiration.nducing sleep and relieving anxiety. Thephysiological role of adenosine is thought to be to adjust energy demandsin line with oxygen supply. Many of the clinical actions of methylxanthinesare thought to be mediated through antagonism of adenosine receptors. Foursubtypes of receptor have been identified.esignated A1.2A.2B and A3.
  IPR001634:Adenosine receptor
InterPro domains unassigned to SynO:
G-protein-coupled receptors.PCRs.onstitute a vast protein family that encompasses a wide range of functions (including various autocrine.aracrine and endocrine processes). They show considerable diversity at the sequence level.n the basis of which they can be separated into distinct groups. We use the term clan to describe the GPCRs.s they embrace a group of families for which there are indications of evolutionary relationship.ut between which there is no statistically significant similarity in sequence . The currently known clan members include the rhodopsin-like GPCRs.he secretin-like GPCRs.he cAMP receptors.he fungal mating pheromone receptors.nd the metabotropic glutamate receptor family. There is a specialized database for GPCRs: http://www.gpcr.org/7tm/. The rhodopsin-like GPCRs themselves represent a widespread protein family that includes hormone.eurotransmitter and light receptors.ll of which transduce extracellular signals through interaction with guanine nucleotide-binding (G) proteins. Although their activating ligands vary widely in structure and character.he amino acid sequences of the receptors are very similar and are believed to adopt a common structural framework comprising 7transmembrane (TM) helices .
  IPR000276:Rhodopsin-like GPCR superfamily
G-protein-coupled receptors.PCRs.onstitute a vast protein family that encompasses a wide range of functions (including various autocrine.aracrine and endocrine processes). They show considerable diversity at the sequence level.n the basis of which they can be separated into distinct groups. We use the term clan to describe the GPCRs.s they embrace a group of families for which there are indications of evolutionary relationship.ut between which there is no statistically significant similarity in sequence . The currently known clan members include the rhodopsin-like GPCRs.he secretin-like GPCRs.he cAMP receptors.he fungal mating pheromone receptors.nd the metabotropic glutamate receptor family. There is a specialized database for GPCRs: http://www.gpcr.org/7tm/. The rhodopsin-like GPCRs themselves represent a widespread protein family that includes hormone.eurotransmitter and light receptors.ll of which transduce extracellular signals through interaction with guanine nucleotide-binding (G) proteins. Although their activating ligands vary widely in structure and character.he amino acid sequences of the receptors are very similar and are believed to adopt a common structural framework comprising 7transmembrane (TM) helices .In addition to their role in energy metabolism.urines (especiallyadenosine and adenine nucleotides) produce a wide range of pharmacologicaleffects mediated by activation of cell surface receptors . Distinctreceptors exist for adenosine. In the periphery.he main effects ofadenosine include vasodilation.ronchoconstriction.mmunosuppresion.nhibition of platelet aggregation.ardiac depression.timulation ofnociceptive afferents.nhibition of neurotransmitter release andinhibition of the release of other factors..g. hormones . In the CNS.denosine exerts a pre- and post-synaptic depressant action.educing motoractivity.epressing respiration.nducing sleep and relieving anxiety. Thephysiological role of adenosine is thought to be to adjust energy demandsin line with oxygen supply. Many of the clinical actions of methylxanthinesare thought to be mediated through antagonism of adenosine receptors. Foursubtypes of receptor have been identified.esignated A1.2A.2B and A3.A2A receptors have a limited distribution in the brain and are found in thestriatum.lfactory tubercle and nucleus accumbens. In the periphery.2receptors mediate vasodilation.mmunosuppression.nhibition of plateletaggregation and gluconeogenesis . The receptors activate adenylyl cyclase through G proteins.
  IPR001513:Adenosine A2A receptor
IPR000276:7tm_1 
Evalue:-73.958610534668 
Location:23-288IPR001513:ADENOSINA2AR 
Evalue:0 
Location:327-346IPR001513:ADENOSINA2AR 
Evalue:0 
Location:347-365IPR001513:ADENOSINA2AR 
Evalue:0 
Location:304-321IPR001634:ADENOSINER 
Evalue:0 
Location:7-16
SequencesProtein: AA2AR_HUMAN (412 aa)
mRNA: M97370 NM_000675
Local Annotation
Synapse Ontology
?
sdb:0219 GPCR mediated signaling  (Evidence:domains)
?
sdb:0305 binding to postsynaptic receptor and internization  (Evidence:domains)
KO assignmentK04266
  Level 3 annotation:
    adenosine A2a receptor
  Level 2 annotation:
    Calcium signaling pathway
    G-protein coupled receptors
    Neuroactive ligand-receptor interaction
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 205 residues, 23159091-23159704Exon2: 593 residues, 23166550-23168324Exon3: 2 residues, -Jump to AA2AR_HUMANExon1: 195 residues, 23159121-23159704Exon2: 593 residues, 23166550-23168324Exon3: 2 residues, -Jump to AA2AR_HUMAN  
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