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0AA1R_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameADORA1
DescriptionAdenosine a1 receptor.
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005887 integral to plasma membrane (TAS)
0007267 cell-cell signaling (TAS)
0008624 induction of apoptosis by extracellular sig... (TAS)
0006954 inflammatory response (TAS)
0007399 neurogenesis (TAS)
0006909 phagocytosis (TAS)
0007165 signal transduction (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains assigned to SynO:
G-protein-coupled receptors.PCRs.onstitute a vast protein family that encompasses a wide range of functions (including various autocrine.aracrine and endocrine processes). They show considerable diversity at the sequence level.n the basis of which they can be separated into distinct groups. We use the term clan to describe the GPCRs.s they embrace a group of families for which there are indications of evolutionary relationship.ut between which there is no statistically significant similarity in sequence . The currently known clan members include the rhodopsin-like GPCRs.he secretin-like GPCRs.he cAMP receptors.he fungal mating pheromone receptors.nd the metabotropic glutamate receptor family. There is a specialized database for GPCRs: http://www.gpcr.org/7tm/. The rhodopsin-like GPCRs themselves represent a widespread protein family that includes hormone.eurotransmitter and light receptors.ll of which transduce extracellular signals through interaction with guanine nucleotide-binding (G) proteins. Although their activating ligands vary widely in structure and character.he amino acid sequences of the receptors are very similar and are believed to adopt a common structural framework comprising 7transmembrane (TM) helices .In addition to their role in energy metabolism.urines (especiallyadenosine and adenine nucleotides) produce a wide range of pharmacologicaleffects mediated by activation of cell surface receptors . Distinctreceptors exist for adenosine. In the periphery.he main effects ofadenosine include vasodilation.ronchoconstriction.mmunosuppresion.nhibition of platelet aggregation.ardiac depression.timulation ofnociceptive afferents.nhibition of neurotransmitter release andinhibition of the release of other factors..g. hormones . In the CNS.denosine exerts a pre- and post-synaptic depressant action.educing motoractivity.epressing respiration.nducing sleep and relieving anxiety. Thephysiological role of adenosine is thought to be to adjust energy demandsin line with oxygen supply. Many of the clinical actions of methylxanthinesare thought to be mediated through antagonism of adenosine receptors. Foursubtypes of receptor have been identified.esignated A1.2A.2B and A3.
  IPR001634:Adenosine receptor
InterPro domains unassigned to SynO:
G-protein-coupled receptors.PCRs.onstitute a vast protein family that encompasses a wide range of functions (including various autocrine.aracrine and endocrine processes). They show considerable diversity at the sequence level.n the basis of which they can be separated into distinct groups. We use the term clan to describe the GPCRs.s they embrace a group of families for which there are indications of evolutionary relationship.ut between which there is no statistically significant similarity in sequence . The currently known clan members include the rhodopsin-like GPCRs.he secretin-like GPCRs.he cAMP receptors.he fungal mating pheromone receptors.nd the metabotropic glutamate receptor family. There is a specialized database for GPCRs: http://www.gpcr.org/7tm/. The rhodopsin-like GPCRs themselves represent a widespread protein family that includes hormone.eurotransmitter and light receptors.ll of which transduce extracellular signals through interaction with guanine nucleotide-binding (G) proteins. Although their activating ligands vary widely in structure and character.he amino acid sequences of the receptors are very similar and are believed to adopt a common structural framework comprising 7transmembrane (TM) helices .
  IPR000276:Rhodopsin-like GPCR superfamily
G-protein-coupled receptors.PCRs.onstitute a vast protein family that encompasses a wide range of functions (including various autocrine.aracrine and endocrine processes). They show considerable diversity at the sequence level.n the basis of which they can be separated into distinct groups. We use the term clan to describe the GPCRs.s they embrace a group of families for which there are indications of evolutionary relationship.ut between which there is no statistically significant similarity in sequence . The currently known clan members include the rhodopsin-like GPCRs.he secretin-like GPCRs.he cAMP receptors.he fungal mating pheromone receptors.nd the metabotropic glutamate receptor family. There is a specialized database for GPCRs: http://www.gpcr.org/7tm/. The rhodopsin-like GPCRs themselves represent a widespread protein family that includes hormone.eurotransmitter and light receptors.ll of which transduce extracellular signals through interaction with guanine nucleotide-binding (G) proteins. Although their activating ligands vary widely in structure and character.he amino acid sequences of the receptors are very similar and are believed to adopt a common structural framework comprising 7transmembrane (TM) helices .In addition to their role in energy metabolism.urines (especiallyadenosine and adenine nucleotides) produce a wide range of pharmacologicaleffects mediated by activation of cell surface receptors. Distinctreceptors exist for adenosine. In the periphery.he main effects ofadenosine include vasodilation.ronchoconstriction.mmunosuppresion.nhibition of platelet aggregation.ardiac depression.timulation ofnociceptive afferents.nhibition of neurotransmitter release andinhibition of the release of other factors..g. hormones . In the CNS.denosine exerts a pre- and post-synaptic depressant action.educing motoractivity.epressing respiration.nducing sleep and relieving anxiety. Thephysiological role of adenosine is thought to be to adjust energy demandsin line with oxygen supply. Many of the clinical actions of methylxanthinesare thought to be mediated through antagonism of adenosine receptors. Foursubtypes of receptor have been identified.esignated A1.2A.2B and A3.A1 receptors are distributed widely in peripheral tissues (e.g..eart.dipose tissue.idney.tomach and pancreas).here they have a mainlyinhibitory role.nd are also found in peripheral nerves (e.g..n theintestine and vas deferens) . In the CNS.hey are present in highlevels.otably in the cerebral cortex.ippocampus.erebellum.halamusand striatum. The receptors inhibit adenylyl cyclase and voltage-dependentcalcium channels.nd activate potassium channels through a pertussis-toxin-sensitive G-protein.robably of the Gi/Go class.
  IPR001068:Adenosine A1 receptor
IPR000276:7tm_1 
Evalue:-65.1023712158203 
Location:26-288IPR001068:ADENOSINEA1R 
Evalue:0 
Location:297-310IPR001068:ADENOSINEA1R 
Evalue:0 
Location:5-15
SequencesProtein: AA1R_HUMAN (326 aa)
mRNA: NM_000674
Local Annotation
Synapse Ontology
?
sdb:0219 GPCR mediated signaling  (Evidence:domains)
?
sdb:0305 binding to postsynaptic receptor and internization  (Evidence:domains)
KO assignmentK04265
  Level 3 annotation:
    adenosine A1 receptor
  Level 2 annotation:
    G-protein coupled receptors
    Neuroactive ligand-receptor interaction
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 28 residues, 201326404-201326485Exon2: 8 residues, 201327443-201327461Exon3: 35 residues, 201363579-201363679Exon4: 53 residues, 201364028-201364183Exon5: 134 residues, 201364535-201364933Exon6: 716 residues, 201401011-201403155Exon7: 2 residues, -Jump to AA1R_HUMAN  
Tune and view alternative isoforms
Loci Cluster (Details)Loci: 2582 201243158-201259290 ~-16K 3694(C1orf37)(+)Loci: 2583 201326404-201403155 ~-77K 3698(ADORA1)(+)Loci: 3859 200831778-200946039 ~-114K 3683(SYT2)(-)Link out to UCSC