SynDB Home Page
SynDB Home Page
Browse
Search
Download
Help
People
links

blue bulletSynDB protein details  


Parse error: syntax error, unexpected T_VARIABLE in /home/kongl/syndb/www/sdb_nats.php on line 52
05HT7R_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameHTR7
Description5-hydroxytryptamine 7 receptor (5-ht-7) (serotonin receptor 7) (5-ht- x) (5ht7).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005887 integral to plasma membrane (TAS)
0004993 serotonin receptor activity (TAS)
0007623 circadian rhythm (TAS)
0008015 circulation (TAS)
0007187 G-protein signaling, coupled to cyclic nucl... (TAS)
0007268 synaptic transmission (TAS)

Warning: fopen(/home/kongl/syndb/www/temp/1805837420.dot) [function.fopen]: failed to open stream: Permission denied in /home/kongl/syndb/www/sdb_pro.php on line 269

Warning: fwrite(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 270

Warning: fwrite(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 271

Warning: fwrite(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 272

Warning: fwrite(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 273

Warning: fwrite(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 274

Warning: fwrite(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 299

Warning: fclose(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 300
schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
G-protein-coupled receptors.PCRs.onstitute a vast protein family that encompasses a wide range of functions (including various autocrine.aracrine and endocrine processes). They show considerable diversity at the sequence level.n the basis of which they can be separated into distinct groups. We use the term clan to describe the GPCRs.s they embrace a group of families for which there are indications of evolutionary relationship.ut between which there is no statistically significant similarity in sequence . The currently known clan members include the rhodopsin-like GPCRs.he secretin-like GPCRs.he cAMP receptors.he fungal mating pheromone receptors.nd the metabotropic glutamate receptor family. There is a specialized database for GPCRs: http://www.gpcr.org/7tm/. The rhodopsin-like GPCRs themselves represent a widespread protein family that includes hormone.eurotransmitter and light receptors.ll of which transduce extracellular signals through interaction with guanine nucleotide-binding (G) proteins. Although their activating ligands vary widely in structure and character.he amino acid sequences of the receptors are very similar and are believed to adopt a common structural framework comprising 7transmembrane (TM) helices .
  IPR000276:Rhodopsin-like GPCR superfamily
G-protein-coupled receptors.PCRs.onstitute a vast protein family that encompasses a wide range of functions (including various autocrine.aracrine and endocrine processes). They show considerable diversity at the sequence level.n the basis of which they can be separated into distinct groups. We use the term clan to describe the GPCRs.s they embrace a group of families for which there are indications of evolutionary relationship.ut between which there is no statistically significant similarity in sequence . The currently known clan members include the rhodopsin-like GPCRs.he secretin-like GPCRs.he cAMP receptors.he fungal mating pheromone receptors.nd the metabotropic glutamate receptor family. There is a specialized database for GPCRs: http://www.gpcr.org/7tm/. The rhodopsin-like GPCRs themselves represent a widespread protein family that includes hormone.eurotransmitter and light receptors.ll of which transduce extracellular signals through interaction with guanine nucleotide-binding (G) proteins. Although their activating ligands vary widely in structure and character.he amino acid sequences of the receptors are very similar and are believed to adopt a common structural framework comprising 7transmembrane (TM) helices .5-Hydroxytryptamine (or serotonin) is ubiquitous in plants and animals. It is an important neurotransmitter and local hormone in the CNS and intestine.nd is implicated in a vast array of physiological and pathophysiological pathways. In the periphery.HT contracts a number of smooth muscles.nd induces endothelium-dependent vasodilation through the formation of NO. It is a mediator of peristalsis.nd may be involved in platelet aggregation and homeostasis. In the CNS.HT is believed to be involved in a wide range of functions.ncluding the control of appetite.ood.nxiety.allucinations.leep.omiting and pain perception 5HT receptor ligands are of clinical use in the treatment of depression.igraine and post-operative vomiting.Numerous receptor subtypes have been classified according to their antagonist susceptibilities and their affinities for 5HT. Five 5HT1 subtypes and at least three 5HT2 subtypes have now been identified.n addition to subtypes 5HT3-7 . All share a high degree of sequence similarity.nd have overlapping pharmacological specificities.The 5HT2 receptor was originally classified according to its ability todisplay micromolar affinity for 5HT.o be labelled with spiperone.nd by its susceptibility to 5HT antagonists . At least 3 members ofthe family exist (including the re-classified 5HT1C receptor).ll ofwhich share a high degree of sequence similarity and stimulate thephosphoinositide pathway.
  IPR001069:5-Hydroxytryptamine 7 receptor
G-protein-coupled receptors.PCRs.onstitute a vast protein family that encompasses a wide range of functions (including various autocrine.aracrine and endocrine processes). They show considerable diversity at the sequence level.n the basis of which they can be separated into distinct groups. We use the term clan to describe the GPCRs.s they embrace a group of families for which there are indications of evolutionary relationship.ut between which there is no statistically significant similarity in sequence . The currently known clan members include the rhodopsin-like GPCRs.he secretin-like GPCRs.he cAMP receptors.he fungal mating pheromone receptors.nd the metabotropic glutamate receptor family. There is a specialized database for GPCRs: http://www.gpcr.org/7tm/. The rhodopsin-like GPCRs themselves represent a widespread protein family that includes hormone.eurotransmitter and light receptors.ll of which transduce extracellular signals through interaction with guanine nucleotide-binding (G) proteins. Although their activating ligands vary widely in structure and character.he amino acid sequences of the receptors are very similar and are believed to adopt a common structural framework comprising 7transmembrane (TM) helices .Adrenocorticotrophin (ACTH).elanocyte-stimulating hormones (MSH) andbeta-endorphin are peptide products of pituitary pro-opiomelanocortin.ACTH regulates synthesis and release of glucocorticoids and aldosteronein the adrenal cortex; it also has a trophic action on these cells.ACTH and beta-endorphin are synthesised and released in response tocorticotrophin-releasing factor at times of stress (heat.old.nfections.tc.) - their release leads to increased metabolism and analgesia res..MSH has a trophic action on melanocytes.nd regulates pigment productionin fish and amphibia . The ACTH receptor is found in high levels inthe adrenal cortex - binding sites are present in lower levels in theCNS. The MSH receptor is expressed in high levels in melanocytes.elanomas and their derived cell lines . Receptors are found in lowlevels in the CNS. MSH regulates temperature control in the septal regionof the brain and releases prolactin from the pituitary.
  IPR001671:Melanocortin/ACTH receptor
IPR000276:7tm_1 
Evalue:-97.4948501586914 
Location:98-384IPR001069:5HT7RECEPTR 
Evalue:0 
Location:422-443IPR001069:5HT7RECEPTR 
Evalue:0 
Location:30-50IPR001069:5HT7RECEPTR 
Evalue:0 
Location:2-22IPR001069:5HT7RECEPTR 
Evalue:0 
Location:51-70IPR001069:5HT7RECEPTR 
Evalue:0 
Location:404-421IPR001671:MCRFAMILY 
Evalue:0 
Location:388-401
SequencesProtein: 5HT7R_HUMAN (479 aa)
mRNA: NM_019859
Local Annotation
Synapse Ontology
?
sdb:0328 transmitters release and endocytosis  (Evidence:keywords)
KO assignmentK04163
  Level 3 annotation:
    5-hydroxytryptamine (serotonin) receptor 7
  Level 2 annotation:
    Calcium signaling pathway
    G-protein coupled receptors
    Neuroactive ligand-receptor interaction
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 570 residues, 92490557-92492265Exon2: 34 residues, 92493329-92493427Exon3: 254 residues, 92498575-92499331Exon4: 262 residues, 92606869-92607651Exon5: 2 residues, -Jump to 5HT7R_HUMAN  
Tune and view alternative isoforms