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05HT4R_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameHTR4
Description5-hydroxytryptamine 4 receptor (5-ht-4) (serotonin receptor 4) (5- ht4).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005887 integral to plasma membrane (TAS)
0004993 serotonin receptor activity (TAS)
0007187 G-protein signaling, coupled to cyclic nucl... (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains assigned to SynO:
G-protein-coupled receptors.PCRs.onstitute a vast protein family that encompasses a wide range of functions (including various autocrine.aracrine and endocrine processes). They show considerable diversity at the sequence level.n the basis of which they can be separated into distinct groups. We use the term clan to describe the GPCRs.s they embrace a group of families for which there are indications of evolutionary relationship.ut between which there is no statistically significant similarity in sequence . The currently known clan members include the rhodopsin-like GPCRs.he secretin-like GPCRs.he cAMP receptors.he fungal mating pheromone receptors.nd the metabotropic glutamate receptor family. There is a specialized database for GPCRs: http://www.gpcr.org/7tm/. The rhodopsin-like GPCRs themselves represent a widespread protein family that includes hormone.eurotransmitter and light receptors.ll of which transduce extracellular signals through interaction with guanine nucleotide-binding (G) proteins. Although their activating ligands vary widely in structure and character.he amino acid sequences of the receptors are very similar and are believed to adopt a common structural framework comprising 7transmembrane (TM) helices .5-Hydroxytryptamine (or serotonin) is ubiquitous in plants and animals. It is an important neurotransmitter and local hormone in the CNS and intestine.nd is implicated in a vast array of physiological and pathophysiological pathways. In the periphery.HT contracts a number of smooth muscles.nd induces endothelium-dependent vasodilation through the formation of NO. It is a mediator of peristalsis.nd may be involved in platelet aggregation and homeostasis. In the CNS.HT is believed to be involved in a wide range of functions.ncluding the control of appetite.ood.nxiety.allucinations.leep.omiting and pain perception 5HT receptor ligands are of clinical use in the treatment of depression.igraine and post-operative vomiting.Numerous receptor subtypes have been classified according to their antagonist susceptibilities and their affinities for 5HT. Five 5HT1 subtypes and at least three 5HT2 subtypes have now been identified.n addition to subtypes 5HT3-7 . All share a high degree of sequence similarity.nd have overlapping pharmacological specificities.The 5HT4 receptor is found in neurons in the CNS.ith highest levels incolliculus and hippocampus. In the periphery.t is found in myentericneurons in ileum and in smoothe muscle (e.g..at oesophagus and heartmuscle). The receptor is linked to the adenylyl cyclase pathway viaG proteins .
  IPR001520:5-Hydroxytryptamine 4 receptor
InterPro domains unassigned to SynO:
G-protein-coupled receptors.PCRs.onstitute a vast protein family that encompasses a wide range of functions (including various autocrine.aracrine and endocrine processes). They show considerable diversity at the sequence level.n the basis of which they can be separated into distinct groups. We use the term clan to describe the GPCRs.s they embrace a group of families for which there are indications of evolutionary relationship.ut between which there is no statistically significant similarity in sequence . The currently known clan members include the rhodopsin-like GPCRs.he secretin-like GPCRs.he cAMP receptors.he fungal mating pheromone receptors.nd the metabotropic glutamate receptor family. There is a specialized database for GPCRs: http://www.gpcr.org/7tm/. The rhodopsin-like GPCRs themselves represent a widespread protein family that includes hormone.eurotransmitter and light receptors.ll of which transduce extracellular signals through interaction with guanine nucleotide-binding (G) proteins. Although their activating ligands vary widely in structure and character.he amino acid sequences of the receptors are very similar and are believed to adopt a common structural framework comprising 7transmembrane (TM) helices .
  IPR000276:Rhodopsin-like GPCR superfamily
G-protein-coupled receptors.PCRs.onstitute a vast protein family that encompasses a wide range of functions (including various autocrine.aracrine and endocrine processes). They show considerable diversity at the sequence level.n the basis of which they can be separated into distinct groups. We use the term clan to describe the GPCRs.s they embrace a group of families for which there are indications of evolutionary relationship.ut between which there is no statistically significant similarity in sequence . The currently known clan members include the rhodopsin-like GPCRs.he secretin-like GPCRs.he cAMP receptors.he fungal mating pheromone receptors.nd the metabotropic glutamate receptor family. There is a specialized database for GPCRs: http://www.gpcr.org/7tm/. The rhodopsin-like GPCRs themselves represent a widespread protein family that includes hormone.eurotransmitter and light receptors.ll of which transduce extracellular signals through interaction with guanine nucleotide-binding (G) proteins. Although their activating ligands vary widely in structure and character.he amino acid sequences of the receptors are very similar and are believed to adopt a common structural framework comprising 7transmembrane (TM) helices .In the periphery.he adrenergic system plays an important role in regulating the cardiovascular system . Increased sympathetic discharge to the heart increases the rate and force of contraction mediated through beta-1 receptors. Circulating adrenaline also acts on cardiac tissue.nd.n addition.cts both on alpha-1 adrenoceptors in arterial smooth muscle.timulating vasoconstriction.nd on beta-2 adrenoceptors in vascular beds of skeletal muscle.timulating vasodilation. In the CNS.oradrenaline is thought to be involved in the regulation of mood.nd various psychoactive drugs alter noradrenergic function. Numerous drugs exert their actions via adrenoceptors: e.g..eta-2 selective agonists such as salbutamol are used in the acute treatment of asthma.hile alpha agonists prolong the action of local anaesthetics.nd act as nasal decongestants . Adrenoceptors can be divided into three main classes based on sequence similarity.eceptor pharmacology and signalling mechanisms. Further subdivisions exist within each class. A large number of agonists and antagonists distinguish between the different classes of adrenoceptor; by contrast.elatively small differences in agonist and antagonist affinities are demonstrated.specially within the alpha-1 and alpha-2 adrenoceptor subtypes .
  IPR002233:Adrenergic receptor
IPR000276:7tm_1 
Evalue:-75.6777801513672 
Location:36-312IPR001520:5HT4RECEPTR 
Evalue:0 
Location:337-359IPR001520:5HT4RECEPTR 
Evalue:0 
Location:2-19IPR002233:ADRENERGICR 
Evalue:0 
Location:318-327
SequencesProtein: 5HT4R_HUMAN (388 aa)
mRNA: AJ131726 NM_000870
Local Annotation
Synapse Ontology
?
sdb:0219 GPCR mediated signaling  (Evidence:keywords,domains)
Calcium release from RyR (Ryanodine Receptor) in the SR (Sarcoplasmic Reticulum) is activated by the calcium induced-calcium-release
sdb:0325 RyR-CICR  (Evidence:keywords,domains)
?
sdb:0328 transmitters release and endocytosis  (Evidence:keywords,domains)
KO assignmentK04160
  Level 3 annotation:
    5-hydroxytryptamine (serotonin) receptor 4
  Level 2 annotation:
    Calcium signaling pathway
    G-protein coupled receptors
    Neuroactive ligand-receptor interaction
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 587 residues, 147841291-147843049Exon2: 191 residues, 147869211-147869780Exon3: 53 residues, 147882948-147883102Exon4: 69 residues, 147908423-147908624Exon5: 44 residues, 147909892-147910018Exon6: 26 residues, 147996744-147996817Exon7: 32 residues, 148013817-148013909Exon8: 2 residues, -Jump to 5HT4R_HUMANExon1: 113 residues, 147842712-147843049Exon2: 42 residues, 147844015-147844135Exon3: 191 residues, 147869211-147869780Exon4: 53 residues, 147882948-147883102Exon5: 69 residues, 147908423-147908624Exon6: 44 residues, 147909892-147910018Exon7: 12 residues, 147996744-147996776Exon8: 2 residues, -Jump to 5HT4R_HUMAN  
Tune and view alternative isoforms
Loci Cluster (Details)Loci: 3499 148185000-148188447 ~-3K 29722(ADRB2)(+)Loci: 4741 148364376-148422880 ~-59K 29724(SH3TC2)(-)Loci: 3500 148705284-148714338 ~-9K 29730(GRPEL2)(+)Loci: 4742 148855037-148911200 ~-56K 29736(CSNK1A1)(-)Loci: 4740 147841291-148013909 ~-173K 29718(HTR4)(-)Link out to UCSC