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05HT3R_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameHTR3A
Description5-hydroxytryptamine 3 receptor precursor (5-ht-3) (serotonin-gated ion channel receptor) (5-ht3r).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005887 integral to plasma membrane (TAS)
0005230 extracellular ligand-gated ion channel acti... (NAS)
0004872 receptor activity (TAS)
0004993 serotonin receptor activity (NAS)
0005232 serotonin-activated cation-selective channe... (TAS)
0007586 digestion (TAS)
0007268 synaptic transmission (TAS)
0006810 transport (NAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains assigned to SynO:
Neurotransmitter ligand-gated ion channels are transmembrane receptor-ion channel complexes that open transiently upon binding of specific ligands.llowing rapid transmission of signals at chemical synapses .Of the five families known.our have been shown to form a sequence-related superfamily. These are the gamma-aminobutyric acid type A (GABA-A).icotinic acetylcholine.lycine and the serotonin 5HT3 receptors. The ionotropic glutamate receptors () have a distinct primary structure.However.ll these receptors possess a pentameric structure (made up of varying subunits).urrounding a central pore. Each of these subunits contains a large extracellular N-terminal ligand-binding region; 3 hydrophobic transmembrane domains; a large intracellular region; and a fourth hydrophobic domain .This domain represents four transmembrane helices of a variety of neurotransmitter-gated ion-channels.
  IPR006029:Neurotransmitter-gated ion-channel transmembrane region
Neurotransmitter ligand-gated ion channels are transmembrane receptor-ion channel complexes that open transiently upon binding of specific ligands.llowing rapid transmission of signals at chemical synapses .Of the five families known.our have been shown to form a sequence-related superfamily. These are the gamma-aminobutyric acid type A (GABA-A).icotinic acetylcholine.lycine and the serotonin 5HT3 receptors. The ionotropic glutamate receptors () have a distinct primary structure.However.ll these receptors possess a pentameric structure (made up of varying subunits).urrounding a central pore. Each of these subunits contains a large extracellular N-terminal ligand-binding region; 3 hydrophobic transmembrane domains; a large intracellular region; and a fourth hydrophobic domain .This InterPro entry represents the GABA-A.icotinic.lycine.nd 5HT3 receptors.
  IPR006201:Neurotransmitter-gated ion-channel
InterPro domains unassigned to SynO:
Neurotransmitter ligand-gated ion channels are transmembrane receptor-ion channel complexes that open transiently upon binding of specific ligands.llowing rapid transmission of signals at chemical synapses .Of the five families known.our have been shown to form a sequence-related superfamily. These are the gamma-aminobutyric acid type A (GABA-A).icotinic acetylcholine.lycine and the serotonin 5HT3 receptors. The ionotropic glutamate receptors () have a distinct primary structure.However.ll these receptors possess a pentameric structure (made up of varying subunits).urrounding a central pore. Each of these subunits contains a large extracellular N-terminal ligand-binding region; 3 hydrophobic transmembrane domains; a large intracellular region; and a fourth hydrophobic domain .This entry presents the extracellular ligand binding domain of these ion channels. This domain forms a pentameric arrangement in the known structure.
  IPR006202:Neurotransmitter-gated ion-channel ligand-binding
Serotonin (5-hydroxytryptamine.-HT) is widely distributed in both the central and peripheral nervous system.here it acts as a neurotransmitterand neuromodulator . It has been implicated in several aspects of brain function.ncluding regulation of affective states.ngestive behavior and addiction. 5-HT can activate a number of different receptor subtypes that produce diverse neuronal responses.rincipally through activation of G-protein-mediated signalling pathways. Signalling through the 5-HT3 receptor (5-HT3R) differs.ince this subtype belongs to the ligand-gated ion channel (LGIC) superfamily.hich also includes the inhibitory gamma-aminobutyric acid type A and glycine receptors.nd excitatory nicotinic acetylcholine receptors (nAChR) . 5-HT3 receptor function has been implicated in a variety of neural processes.ncluding pain perception.mesis.nxiety and drug abuse. Like the other members of the LGIC superfamily.he 5HT3R exhibits a high degree of sequence similarity.nd therefore putative structural similarity.ith nAChRs . Thus.unctional 5HT3Rs comprise a pentamer: the ion channel is formed at the centre of a rosette formed between five homologous subunits. Two classes of 5-HT3R subunit are currently known.ermed 5-HT3A and 5-HT3B. Whilst homomeric pentamers of 5-HT3A form functional receptors.eteromeric assemblies display channel conductances.ation permeabilities and current-voltage relationships typical of characterised neuronal 5-HT3 channels . The proposed topology of 5-HT3R subunits comprises four putative transmembrane (TM) domains (designated M1-4); a large extracellular N-terminal region (~200 amino acids); and a variable cytoplasmic loop between M3 and M4. The M2 domains from each subunit are thought to form the channel pore. The agonist binding site is formed by the N terminus.hich.n binding.nduces a conformational change in the channel pore. process often referred to as "gating" . Opening of the pore allows cation flux through the neuronal membrane and depolarises the membrane potential. Thus.-HT3Rs may be thought of as excitatory receptors .
  IPR008132:5-hydroxytryptamine 3 receptor
Serotonin (5-hydroxytryptamine.-HT) is widely distributed in both the central and peripheral nervous system.here it acts as a neurotransmitterand neuromodulator . It has been implicated in several aspects of brain function.ncluding regulation of affective states.ngestive behavior and addiction. 5-HT can activate a number of different receptor subtypes that produce diverse neuronal responses.rincipally through activation of G-protein-mediated signalling pathways. Signalling through the 5-HT3 receptor (5-HT3R) differs.ince this subtype belongs to the ligand-gated ion channel (LGIC) superfamily.hich also includes the inhibitory gamma-aminobutyric acid type A and glycine receptors.nd excitatory nicotinic acetylcholine receptors (nAChR) . 5-HT3 receptor function has been implicated in a variety of neural processes.ncluding pain perception.mesis.nxiety and drug abuse. Like the other members of the LGIC superfamily.he 5HT3R exhibits a high degree of sequence similarity.nd therefore putative structural similarity.ith nAChRs . Thus.unctional 5HT3Rs comprise a pentamer: the ion channel is formed at the centre of a rosette formed between five homologous subunits. Two classes of 5-HT3R subunit are currently known.ermed 5-HT3A and 5-HT3B. Whilst homomeric pentamers of 5-HT3A form functional receptors.eteromeric assemblies display channel conductances.ation permeabilities and current-voltage relationships typical of characterised neuronal 5-HT3 channels . The proposed topology of 5-HT3R subunits comprises four putative transmembrane (TM) domains (designated M1-4); a large extracellular N-terminal region (~200 amino acids); and a variable cytoplasmic loop between M3 and M4. The M2 domains from each subunit are thought to form the channel pore. The agonist binding site is formed by the N terminus.hich.n binding.nduces a conformational change in the channel pore. process often referred to as "gating" . Opening of the pore allows cation flux through the neuronal membrane and depolarises the membrane potential. Thus.-HT3Rs may be thought of as excitatory receptors .Cloning of the 5-HT3A subunit from a neuroblastoma expression library was reported in 1991 . Whilst recombinant expression of 5-HT3A yields functional receptors.he channel conductance and permeability to cations are different from that observed for native receptors . Alternative exon splicing gives rise to two isoforms of 5-HT3A.ermed 5-HT3AS and 5-HT3AL for short and long variants.espectively. The 5-HT3RA subunit is widely expressed throughout the peripheral and central nervous systems.ncluding several regions of the brain.
  IPR008133:5-hydroxytryptamine 3 receptor, A subunit
IPR006202:Neur_chan_LBD 
Evalue:-75.853874206543 
Location:34-242IPR006029:Neur_chan_memb 
Evalue:-50.9208183288574 
Location:249-469IPR001005:MYB_2 
Evalue:0 
Location:0-0
SequencesProtein: 5HT3R_HUMAN (478 aa)
mRNA: NM_000869 NM_213621
Local Annotation
Synapse Ontology
Postsynaptic compartment is represented by a patch of plasma membrane containing a packed array of neurotransmitter receptors and by an underlying dense matrix, the postsynaptic density (PSD).
sdb:0005 Postsynaptic compartment  (Evidence:keywords,domains)
this kind of receptor usually locates at the postsynaptic plasma membranous region.
sdb:0109 ionotropic receptor  (Evidence:keywords,domains)
priming for exocytosis prepares the calcium-dependent release and may involve partial fusion process. The vesicles are primed and become responsive to calcium.
sdb:0120 priming  (Evidence:keywords,domains)
?
sdb:0305 binding to postsynaptic receptor and internization  (Evidence:keywords,domains)
?
sdb:0328 transmitters release and endocytosis  (Evidence:keywords,domains)
KO assignmentK04819
  Level 3 annotation:
    5-hydroxytryptamine (serotonin) receptor 3A
  Level 2 annotation:
    Ion channels
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 69 residues, 113351119-113351324Exon2: 52 residues, 113353702-113353854Exon3: 17 residues, 113355164-113355209Exon4: 38 residues, 113357134-113357244Exon5: 58 residues, 113359051-113359221Exon6: 55 residues, 113361946-113362107Exon7: 72 residues, 113362449-113362660Exon8: 76 residues, 113362756-113362978Exon9: 284 residues, 113365396-113366242Exon10: 2 residues, -Jump to 5HT3R_HUMANExon1: 69 residues, 113351119-113351324Exon2: 52 residues, 113353702-113353854Exon3: 17 residues, 113355164-113355209Exon4: 38 residues, 113357134-113357244Exon5: 58 residues, 113359051-113359221Exon6: 55 residues, 113361946-113362107Exon7: 178 residues, 113362449-113362978Exon8: 284 residues, 113365396-113366242Exon9: 2 residues, -Jump to 5HT3R_HUMAN  
Tune and view alternative isoforms
Loci Cluster (Details)Loci: 3992 113063482-113082305 ~-19K 7767(TMPRSS5)(-)Loci: 3993 113109120-113149635 ~-41K 7769(ZW10)(-)Loci: 2706 113280798-113322492 ~-42K 7774(+)Loci: 2707 113351119-113366242 ~-15K 7775(HTR3A)(+)Loci: 2708 113435640-113626604 ~-191K 7782(ZBTB16)(+)Loci: 3991 112785527-112851091 ~-66K 7762(DRD2)(-)Link out to UCSC