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05HT1F_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameHTR1F
Description5-hydroxytryptamine 1f receptor (5-ht-1f) (serotonin receptor 1f).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005887 integral to plasma membrane (TAS)
0004993 serotonin receptor activity (TAS)
0007187 G-protein signaling, coupled to cyclic nucl... (TAS)
0007268 synaptic transmission (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains assigned to SynO:
G-protein-coupled receptors.PCRs.onstitute a vast protein family that encompasses a wide range of functions (including various autocrine.aracrine and endocrine processes). They show considerable diversity at the sequence level.n the basis of which they can be separated into distinct groups. We use the term clan to describe the GPCRs.s they embrace a group of families for which there are indications of evolutionary relationship.ut between which there is no statistically significant similarity in sequence . The currently known clan members include the rhodopsin-like GPCRs.he secretin-like GPCRs.he cAMP receptors.he fungal mating pheromone receptors.nd the metabotropic glutamate receptor family. There is a specialized database for GPCRs: http://www.gpcr.org/7tm/. The rhodopsin-like GPCRs themselves represent a widespread protein family that includes hormone.eurotransmitter and light receptors.ll of which transduce extracellular signals through interaction with guanine nucleotide-binding (G) proteins. Although their activating ligands vary widely in structure and character.he amino acid sequences of the receptors are very similar and are believed to adopt a common structural framework comprising 7transmembrane (TM) helices .5-Hydroxytryptamine (or serotonin) is ubiquitous in plants and animals. It is an important neurotransmitter and local hormone in the CNS and intestine.nd is implicated in a vast array of physiological and pathophysiological pathways. In the periphery.HT contracts a number of smooth muscles.nd induces endothelium-dependent vasodilation through the formation of NO. It is a mediator of peristalsis.nd may be involved in platelet aggregation and homeostasis. In the CNS.HT is believed to be involved in a wide range of functions.ncluding the control of appetite.ood.nxiety.allucinations.leep.omiting and pain perception 5HT receptor ligands are of clinical use in the treatment of depression.igraine and post-operative vomiting.Numerous receptor subtypes have been classified according to their antagonist susceptibilities and their affinities for 5HT. Five 5HT1 subtypes and at least three 5HT2 subtypes have now been identified.n addition to subtypes 5HT3-7 . All share a high degree of sequence similarity.nd have overlapping pharmacological specificities.
  IPR002231:5-Hydroxytryptamine receptor
InterPro domains unassigned to SynO:
G-protein-coupled receptors.PCRs.onstitute a vast protein family that encompasses a wide range of functions (including various autocrine.aracrine and endocrine processes). They show considerable diversity at the sequence level.n the basis of which they can be separated into distinct groups. We use the term clan to describe the GPCRs.s they embrace a group of families for which there are indications of evolutionary relationship.ut between which there is no statistically significant similarity in sequence . The currently known clan members include the rhodopsin-like GPCRs.he secretin-like GPCRs.he cAMP receptors.he fungal mating pheromone receptors.nd the metabotropic glutamate receptor family. There is a specialized database for GPCRs: http://www.gpcr.org/7tm/. The rhodopsin-like GPCRs themselves represent a widespread protein family that includes hormone.eurotransmitter and light receptors.ll of which transduce extracellular signals through interaction with guanine nucleotide-binding (G) proteins. Although their activating ligands vary widely in structure and character.he amino acid sequences of the receptors are very similar and are believed to adopt a common structural framework comprising 7transmembrane (TM) helices .
  IPR000276:Rhodopsin-like GPCR superfamily
G-protein-coupled receptors.PCRs.onstitute a vast protein family that encompasses a wide range of functions (including various autocrine.aracrine and endocrine processes). They show considerable diversity at the sequence level.n the basis of which they can be separated into distinct groups. We use the term clan to describe the GPCRs.s they embrace a group of families for which there are indications of evolutionary relationship.ut between which there is no statistically significant similarity in sequence . The currently known clan members include the rhodopsin-like GPCRs.he secretin-like GPCRs.he cAMP receptors.he fungal mating pheromone receptors.nd the metabotropic glutamate receptor family. There is a specialized database for GPCRs: http://www.gpcr.org/7tm/. The rhodopsin-like GPCRs themselves represent a widespread protein family that includes hormone.eurotransmitter and light receptors.ll of which transduce extracellular signals through interaction with guanine nucleotide-binding (G) proteins. Although their activating ligands vary widely in structure and character.he amino acid sequences of the receptors are very similar and are believed to adopt a common structural framework comprising 7transmembrane (TM) helices .5-Hydroxytryptamine (or serotonin) is ubiquitous in plants and animals. It is an important neurotransmitter and local hormone in the CNS and intestine.nd is implicated in a vast array of physiological and pathophysiological pathways. In the periphery.HT contracts a number of smooth muscles.nd induces endothelium-dependent vasodilation through the formation of NO. It is a mediator of peristalsis.nd may be involved in platelet aggregation and homeostasis. In the CNS.HT is believed to be involved in a wide range of functions.ncluding the control of appetite.ood.nxiety.allucinations.leep.omiting and pain perception 5HT receptor ligands are of clinical use in the treatment of depression.igraine and post-operative vomiting.Numerous receptor subtypes have been classified according to their antagonist susceptibilities and their affinities for 5HT. Five 5HT1 subtypes and at least three 5HT2 subtypes have now been identified.n addition to subtypes 5HT3-7 . All share a high degree of sequence similarity.nd have overlapping pharmacological specificities.5HT1-like receptors were originally classified according to their nanomolar affinity for 5HT.usceptibility to antagonism by methiothepin and/ormethysegide.esistance to antagonism by 5HT2 and 5HT3 antagonists.ndhigh affinity for the agonist 5-carboxamidotryptamine. Five subtypesof 5HT1-like receptors have now been identified - these do not fit all theabove criteria.nd 5HT1C has been reclassified 5HT2C . All are linkedto the inhibition of adenylyl cyclase.hare a high degree of sequencesimilarity.nd have overlapping pharmacological specificities.The 5HT1F receptor has limited distribution in peripheral tissues and hasbeen detected only in the uterus and mesentary. In the CNS.RNA ispresent in the cerebral cortex.ippocampus.aphe and spinal cord.Elucidation of its physiological role will require development of selectiveligands. There are no selective antagonists or agonists - the 5HT1Dagonist sumatriptan has reasonable affinity .
  IPR000450:5-Hydroxytryptamine 1F receptor
IPR000276:7tm_1 
Evalue:-84.7958831787109 
Location:40-347IPR000450:5HT1FRECEPTR 
Evalue:0 
Location:15-29IPR002231:5HTRECEPTOR 
Evalue:0 
Location:348-353
SequencesProtein: 5HT1F_HUMAN (366 aa)
mRNA: NM_000866
Local Annotation
Synapse Ontology
?
sdb:0219 GPCR mediated signaling  (Evidence:keywords,domains)
Calcium release from RyR (Ryanodine Receptor) in the SR (Sarcoplasmic Reticulum) is activated by the calcium induced-calcium-release
sdb:0325 RyR-CICR  (Evidence:keywords,domains)
?
sdb:0328 transmitters release and endocytosis  (Evidence:keywords,domains)
KO assignmentK04156
  Level 3 annotation:
    5-hydroxytryptamine (serotonin) receptor 1F
  Level 2 annotation:
    G-protein coupled receptors
    Neuroactive ligand-receptor interaction
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 368 residues, 88122589-88123690Exon2: 2 residues, -Jump to 5HT1F_HUMAN  
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