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04F2_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameSLC3A2
Description4f2 cell-surface antigen heavy chain (4f2hc) (lymphocyte activation antigen 4f2 large subunit) (4f2 heavy chain antigen) (cd98 antigen).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0009986 cell surface (IEP)
0016021 integral to membrane (NAS)
0005432 sodium antiporter activity (TAS)
0006865 amino acid transport (TAS)
0006816 calcium ion transport (NAS)
0016049 cell growth (NAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
O-Glycosyl hydrolases (EC 3.2.1.-) are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates.r between a carbohydrate and a non-carbohydrate moiety. A classification system for glycosylhydrolases.ased on sequence similarity.as led to the definition of 85 different families . This classification is available on the CAZy (CArbohydrate-Active EnZymes) web site . Because the fold of proteins is better conserved than their sequences.ome of the families can be grouped in clans. Enzymes containing this domain.uch as alpha-amylase.elong to family 13 () of the glycosyl hydrolases. The maltogenic alpha-amylase is an enzyme which catalyses hydrolysis of (1-4)-alpha-D-glucosidic linkages in polysaccharides so as to remove successive alpha-maltose residues from the non-reducing ends of the chains in the conversion of starch to maltose. Other enzymes include neopullulanase.hich hydrolyses pullulan to panose.nd cyclomaltodextrinase.hich hydrolyses cyclodextrins.This entry represents the catalytic domain found in several protein members of this family. It has a structure consisting of an 8 stranded alpha/beta barrel that contains the active site.nterrupted by a ~70 amino acid calcium-binding domain protruding between beta strand 3 and alpha helix 3.nd a carboxyl-terminal Greek key beta-barrel domain .More information about this protein can be found at Protein of the Month: alpha-Amylase .
  IPR006047:Glycosyl hydrolase, family 13, catalytic region
O-Glycosyl hydrolases (EC 3.2.1.-) are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates.r between a carbohydrate and a non-carbohydrate moiety. A classification system for glycosylhydrolases.ased on sequence similarity.as led to the definition of 85 different families . This classification is available on the CAZy (CArbohydrate-Active EnZymes) web site . Because the fold of proteins is better conserved than their sequences.ome of the families can be grouped in clans.This entry represents the all-beta domain that is found in several members of the glycosyl hydrolase family 13. It is usually located C-terminal to the catalytic beta/alpha barrel domain. This structure of this domain has been found to be a Greek key beta-sheet fold .More information about this protein can be found at Protein of the Month: alpha-Amylase .
  IPR013780:Glycosyl hydrolase, family 13, all-beta
O-Glycosyl hydrolases (EC 3.2.1.-) are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates.r between a carbohydrate and a non-carbohydrate moiety. A classification system for glycosylhydrolases.ased on sequence similarity.as led to the definition of 85 different families . This classification is available on the CAZy (CArbohydrate-Active EnZymes) web site . Because the fold of proteins is better conserved than their sequences.ome of the families can be grouped in clans.This entry represents the catalytic TIM beta/alpha barrel common to many different families of glycosyl hydrolases. Structures have been determined for several proteins containing this domain.ncluding family 13 glycosyl hydrolases (such as alpha-amylase) .eta-glycanases .amily 1 glycosyl hydrolases (such as beta-glucosidase) .ype II chitinases ..-beta-N-acetylmuraminidases .nd beta-N-acetylhexosaminidases .More information about this protein can be found at Protein of the Month: alpha-Amylase .
  IPR013781:Glycoside hydrolase, catalytic core
IPR006047:Alpha-amylase 
Evalue:-8.25181198120117 
Location:174-210IPR013780:Glyco_hydro_13_b 
Evalue:0 
Location:439-525
SequencesProtein: 4F2_HUMAN (529 aa)
mRNA: NM_001012661 NM_001012662 NM_001012663 NM_001012664 NM_001013251 NM_002394
Local Annotation
Synapse Ontology
Microglias, one kind of glias in CNS, are responsible for removing most of the waste and cellular debris from the CNS
sdb:0267 removing metabolic mass  (Evidence:keywords)
KO assignmentK06519
  Level 3 annotation:
    solute carrier family 3, member 2
  Level 2 annotation:
    CD molecules
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 113 residues, 62380093-62380429Exon2: 33 residues, 62394792-62394885Exon3: 33 residues, 62395624-62395717Exon4: 33 residues, 62400834-62400927Exon5: 145 residues, 62405066-62405495Exon6: 60 residues, 62405940-62406114Exon7: 32 residues, 62406955-62407047Exon8: 25 residues, 62408504-62408573Exon9: 21 residues, 62408679-62408738Exon10: 62 residues, 62409224-62409405Exon11: 50 residues, 62409512-62409656Exon12: 30 residues, 62412182-62412266Exon13: 185 residues, 62412378-62412928Exon14: 2 residues, -Jump to 4F2_HUMANExon1: 113 residues, 62380093-62380429Exon2: 33 residues, 62394792-62394885Exon3: 33 residues, 62395624-62395717Exon4: 145 residues, 62405066-62405495Exon5: 60 residues, 62405940-62406114Exon6: 32 residues, 62406955-62407047Exon7: 25 residues, 62408504-62408573Exon8: 21 residues, 62408679-62408738Exon9: 62 residues, 62409224-62409405Exon10: 50 residues, 62409512-62409656Exon11: 30 residues, 62412182-62412266Exon12: 185 residues, 62412378-62412928Exon13: 2 residues, -Jump to 4F2_HUMANExon1: 113 residues, 62380093-62380429Exon2: 33 residues, 62395624-62395717Exon3: 34 residues, 62400831-62400927Exon4: 145 residues, 62405066-62405495Exon5: 60 residues, 62405940-62406114Exon6: 32 residues, 62406955-62407047Exon7: 25 residues, 62408504-62408573Exon8: 21 residues, 62408679-62408738Exon9: 62 residues, 62409224-62409405Exon10: 50 residues, 62409512-62409656Exon11: 30 residues, 62412182-62412266Exon12: 185 residues, 62412378-62412928Exon13: 2 residues, -Jump to 4F2_HUMANExon1: 113 residues, 62380093-62380429Exon2: 33 residues, 62395624-62395717Exon3: 145 residues, 62405066-62405495Exon4: 60 residues, 62405940-62406114Exon5: 32 residues, 62406955-62407047Exon6: 25 residues, 62408504-62408573Exon7: 21 residues, 62408679-62408738Exon8: 62 residues, 62409224-62409405Exon9: 50 residues, 62409512-62409656Exon10: 30 residues, 62412182-62412266Exon11: 185 residues, 62412378-62412928Exon12: 2 residues, -Jump to 4F2_HUMANExon1: 113 residues, 62380093-62380429Exon2: 145 residues, 62405066-62405495Exon3: 60 residues, 62405940-62406114Exon4: 32 residues, 62406955-62407047Exon5: 25 residues, 62408504-62408573Exon6: 21 residues, 62408679-62408738Exon7: 62 residues, 62409224-62409405Exon8: 50 residues, 62409512-62409656Exon9: 30 residues, 62412182-62412266Exon10: 185 residues, 62412378-62412928Exon11: 2 residues, -Jump to 4F2_HUMANExon1: 212 residues, 62404862-62405495Exon2: 60 residues, 62405940-62406114Exon3: 32 residues, 62406955-62407047Exon4: 25 residues, 62408504-62408573Exon5: 21 residues, 62408679-62408738Exon6: 62 residues, 62409224-62409405Exon7: 50 residues, 62409512-62409656Exon8: 30 residues, 62412182-62412266Exon9: 185 residues, 62412378-62412928Exon10: 2 residues, -Jump to 4F2_HUMAN  
Tune and view alternative isoforms
Loci Cluster (Details)Loci: 2668 62137198-62139162 ~-2K 6915(ROM1)(+)Loci: 3955 62148876-62170680 ~-22K 6917(GANAB)(-)Loci: 2669 62252159-62262681 ~-11K 6930(+)Loci: 3956 62330945-62356116 ~-25K 6938(STX5A)(-)Loci: 2670 62380093-62412928 ~-33K 6943(SLC3A2)(+)Loci: 3957 62432727-62445588 ~-13K 6949(CHRM1)(-)Loci: 3954 62117250-62125879 ~-9K 6910(MTA2)(-)Link out to UCSC