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03BHS2_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameHSD3B2
Description3 beta-hydroxysteroid dehydrogenase/delta 5-->4-isomerase type ii (3beta-hsd ii) .
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GON/A
Domain Architecture (Details)
InterPro domains unassigned to SynO:
The enzyme 3 beta-hydroxysteroid dehydrogenase/5-ene-4-ene isomerase (3 beta-HSD) catalyses the oxidation and isomerisation of 5-ene-3 beta-hydroxypregnene and 5-ene-hydroxyandrostene steroid precursors into the corresponding 4-ene-ketosteroids necessaryfor the formation of all classes of steroid hormones.
  IPR002225:3-beta hydroxysteroid dehydrogenase/isomerase
This group represents a bifunctional 3 beta-hydroxysteroid dehydrogenase/delta 5-->4-isomerase.
  IPR012272:Bifunctional 3 beta-hydroxysteroid dehydrogenase/delta 5-->4-isomerase
IPR002225:3Beta_HSD 
Evalue:-173.602066040039 
Location:5-286
SequencesProtein: 3BHS2_HUMAN (371 aa)
mRNA: NM_000198
Local Annotation
Synapse Ontology
mitochondria are frequently observed in the vicinity of the synaptic vesicle clusters, in agreement with the ATP requirement of several steps of the vesicle cycle.
sdb:0118 mitochondria  (Evidence:keywords)
KO assignmentK00070
  Level 3 annotation:
    3beta-hydroxy-delta5-steroid dehydrogenase
  Level 2 annotation:
    C21-Steroid hormone metabolism
    Androgen and estrogen metabolism
K01822
  Level 3 annotation:
    steroid delta-isomerase
  Level 2 annotation:
    C21-Steroid hormone metabolism
    Androgen and estrogen metabolism
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 18 residues, 119759295-119759348Exon2: 79 residues, 119759476-119759707Exon3: 57 residues, 119763563-119763728Exon4: 408 residues, 119765954-119767172Exon5: 2 residues, -Jump to 3BHS2_HUMAN  
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Loci Cluster (Details)Loci: 2544 120056032-120088359 ~-32K 2308(PHGDH)(+)Loci: 3825 120092527-120113041 ~-21K 2310(HMGCS2)(-)Loci: 3826 120255700-120413799 ~-158K 2313(NOTCH2)(-)Loci: 2543 119759295-119767172 ~-8K 2303(HSD3B2)(+)Link out to UCSC