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01433S_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameSFN
Description14-3-3 protein sigma (stratifin) (epithelial cell marker protein 1).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005737 cytoplasm (TAS)
0005615 extracellular space (TAS)
0005515 protein binding (IPI)
0008426 protein kinase C inhibitor activity (TAS)
0008283 cell proliferation (TAS)
0006469 negative regulation of protein kinase activity (TAS)
0000074 regulation of progression through cell cycle (TAS)
0007165 signal transduction (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
The 14-3-3 proteins are a large family of approximately 30kDa acidic proteins which exist primarily as homo- and heterodimeric within all eukaryotic cells. There is a high degree of sequence identity and conservation between all the 14-3-3 isotypes.articularly in the regions which form the dimer interface or line the central ligand binding channel of the dimeric molecule. Each 14-3-3 protein sequence can be roughly divided into three sections: a divergent amino terminus.he conserved core region and a divergent carboxyl terminus. The conserved middle core region of the 14-3-3s encodes an amphipathic groove that forms the main functional domain. cradle for interacting with client proteins. The monomer consists of nine helices organized in an antiparallel manner.orming an L-shaped structure. The interior of the L-structure is composed of four helices: H3 and H5.hich contain many charged and polar amino acids.nd H7 and H9.hich contain hydrophobic amino acids. These four helices form the concave amphipathic groove that interacts with target peptides. 14-3-3 proteins mainly bind proteins containing phosphothreonine or phosphoserine motifs however exceptions to this rule do exist. Extensive investigation of the 14-3-3 binding site of the mammalian serine/threonine kinase Raf-1 has produced a consensus sequence for 14-3-3-binding.SxpSxP (in the single-letter amino-acid code.here x denotes any amino acid and p indicates that the next residue is phosphorylated). 14-3-3 proteins appear to effect intracellular signalling in one of three ways - by direct regulation of the catalytic activity of the bound protein.y regulating interactions between the bound protein and other molecules in the cell by sequestration or modification or by controlling the subcellular localisation of the bound ligand.Proteins appear to initially bind to a single dominant site and then subsequently to many.uch weaker secondary interaction sites. The 14-3-3 dimer is capable of changing the conformation of its bound ligand whilst itself undergoing minimal structural alteration.
  IPR000308:14-3-3 protein
IPR000308:14-3-3 
Evalue:-141.53759765625 
Location:3-238
SequencesProtein: 1433S_HUMAN (248 aa)
mRNA: NM_006142
Local Annotation
Synapse Ontology
activation of protein kinase C
sdb:0206 activation of protein kinase C  (Evidence:keywords)
KO assignmentK06644
  Level 3 annotation:
    stratifin
  Level 2 annotation:
    Cell cycle
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 439 residues, 27062219-27063534Exon2: 2 residues, -Jump to 1433S_HUMAN  
Tune and view alternative isoforms
Loci Cluster (Details)Loci: 2494 27120810-27145474 ~-25K 818(NUDC)(+)Loci: 2495 27192784-27199731 ~-7K 822(+)Loci: 2496 27541099-27553008 ~-12K 833(SYTL1)(+)Loci: 3786 27604712-27689256 ~-85K 852(WASF2)(-)Loci: 2497 27972369-28023401 ~-51K 864(STX12)(+)Loci: 3787 28173405-28287718 ~-114K 879(EYA3)(-)Loci: 2493 27062219-27063534 ~-1K 814(SFN)(+)Link out to UCSC