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01433F_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameYWHAH
Description14-3-3 protein eta (protein as1).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005737 cytoplasm (ISS)
0003779 actin binding (ISS)
0005159 insulin-like growth factor receptor binding (ISS)
0005515 protein binding (ISS)
0008426 protein kinase C inhibitor activity (ISS)
0007010 cytoskeleton organization and biogenesis (ISS)
0043066 negative regulation of apoptosis (ISS)
0006469 negative regulation of protein kinase activity (ISS)
0007088 regulation of mitosis (ISS)
0045664 regulation of neuron differentiation (ISS)
0009966 regulation of signal transduction (ISS)
0048167 regulation of synaptic plasticity (ISS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
The 14-3-3 proteins are a large family of approximately 30kDa acidic proteins which exist primarily as homo- and heterodimeric within all eukaryotic cells. There is a high degree of sequence identity and conservation between all the 14-3-3 isotypes.articularly in the regions which form the dimer interface or line the central ligand binding channel of the dimeric molecule. Each 14-3-3 protein sequence can be roughly divided into three sections: a divergent amino terminus.he conserved core region and a divergent carboxyl terminus. The conserved middle core region of the 14-3-3s encodes an amphipathic groove that forms the main functional domain. cradle for interacting with client proteins. The monomer consists of nine helices organized in an antiparallel manner.orming an L-shaped structure. The interior of the L-structure is composed of four helices: H3 and H5.hich contain many charged and polar amino acids.nd H7 and H9.hich contain hydrophobic amino acids. These four helices form the concave amphipathic groove that interacts with target peptides. 14-3-3 proteins mainly bind proteins containing phosphothreonine or phosphoserine motifs however exceptions to this rule do exist. Extensive investigation of the 14-3-3 binding site of the mammalian serine/threonine kinase Raf-1 has produced a consensus sequence for 14-3-3-binding.SxpSxP (in the single-letter amino-acid code.here x denotes any amino acid and p indicates that the next residue is phosphorylated). 14-3-3 proteins appear to effect intracellular signalling in one of three ways - by direct regulation of the catalytic activity of the bound protein.y regulating interactions between the bound protein and other molecules in the cell by sequestration or modification or by controlling the subcellular localisation of the bound ligand.Proteins appear to initially bind to a single dominant site and then subsequently to many.uch weaker secondary interaction sites. The 14-3-3 dimer is capable of changing the conformation of its bound ligand whilst itself undergoing minimal structural alteration.
  IPR000308:14-3-3 protein
IPR000308:14-3-3 
Evalue:-146.207611083984 
Location:3-240
SequencesProtein: 1433F_HUMAN (245 aa)
mRNA: NM_003405
Local Annotation
Synapse Ontology
A process that modulates synaptic plasticity, the ability of synapses to change as circumstances require. They may alter function, such as increasing or decreasing their sensitivity, or they may increase or decrease in actual numbers.
sdb:0035 regulation of synaptic plasticity  (Evidence:keywords)
activation of protein kinase C
sdb:0206 activation of protein kinase C  (Evidence:keywords)
KO assignmentK06630
  Level 3 annotation:
    tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein
  Level 2 annotation:
    Cell cycle
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 110 residues, 30670478-30670806Exon2: 490 residues, 30682125-30683589Exon3: 2 residues, -Jump to 1433F_HUMAN  
Tune and view alternative isoforms
Loci Cluster (Details)Loci: 3309 30480068-30633000 ~-153K 24579(DEPDC5)(+)Loci: 3310 30670478-30683589 ~-13K 24585(YWHAH)(+)Loci: 4563 30345379-30388195 ~-43K 24575(PISD)(-)Link out to UCSC